5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

Product Name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
CAS No.: 81265-93-2
Chemical Name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
Synonyms: TBS-Bz-rA;TBS-rA(Bz);5'-DMT-2'-TBDMS-Bz-rA;5'-O-DMT-2'-O-TBDMS-Bz-rA;5'-O-DMTr-2'-O-TBDMS-rA(Bz);N6-Bz-2'-O-TBDMS-5'-O-DMT-A;5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine;2'-O-TBDMS-5'-O-DMT-N6-Bz adenosine;N6-Bz-2'-O-TBDMS-5'-O-DMT-adenosine;5'-O-DMT-2'-O-TBDMS-N6-benzoyladenosine
CBNumber: CB52516267
Molecular Formula: C44H49N5O7Si
Formula Weight: 787.97
MOL File: 81265-93-2.mol

More

Less

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine Property

Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.87±0.43(Predicted)
form: Solid
color: White to off-white
InChIKey: DAZIGOPASNJPCJ-OLXVHECFNA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,46,55,r|

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: D494223
Product name: 5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine
Packaging: 2.5g
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 2621AC
Product name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
Packaging: 5g
Price: $252
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB15297
Product name: N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
Packaging: 10g
Price: $265
Updated: 2021/12/16

ChemScene

Product number: CS-0021845
Product name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
Packaging: 5g
Price: $312
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0005202
Product name: 5'-O-DMT-2'-O-TBDMS-N-BZ-ADENOSINE
Purity: 95.00%
Packaging: 250MG
Price: $391.65
Updated: 2021/12/16

More

Less

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine Chemical Properties,Usage,Production

Uses

5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine (CAS# 81265-93-2) is a fluorescent adenosine-containing compound which is often used in for DNA/RNA modifications for detection or the addition of synthetic oligonucleotide blocks.

Synthesis

129666-75-7

18162-48-6

81256-88-4

129681-71-6

Synthesis of N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide from compound (CAS:129666-75-7) and tert-butyldimethylsilylene and the The general procedure for the compound (CAS:129681-71-6) was as follows: to a solution of tetrahydrofuran (THF, 800 mL) and pyridine (15 mL) of the product of the previous step (200 g, 296.9 mmol) was added sequentially silver cyanide (AgNCb, 83.2 g, 489.8 mmol, 1.65 equiv) and tert-butyldimethylchlorosilane ( TBSCl, 78.7 g, 522.5 mmol, 1.76 equiv). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was filtered, diluted with water (H2O, 1.0 L) and extracted with ethyl acetate (EtOAc, 3 x 1.0 L). The organic layers were combined, washed with brine (2 × 1.0 L), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure. The residue was purified by silica gel (SiO2) column chromatography (eluent: petroleum ether/ethyl acetate=3/1 to 1/1) to afford the products D-2a (114 g, 145 mmol, 49% yield) and D-2b (53 g, 68 mmol, 23% yield).

References

[1] Patent: WO2018/156625, 2018, A1. Location in patent: Paragraph 0296
[2] Canadian Journal of Chemistry, 1982, vol. 60, p. 111 - 120

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine Suppliers

China 97 India 2 Switzerland 1 United Kingdom 3 United States 5 Global 108

Allbiosyn Biotechnology Co.,LTD

Tel: +86-18666985712; 18666985712
Email: info@allbiosyn.com
Country: China
ProdList: 297
Advantage: 58

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 255
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Nanjing Baifuli Technology Co., Ltd.

Tel: 25-25-58740604 15951658055
Fax: +86-25-58356858
Email: sales@unisyn.cn
Country: China
ProdList: 591
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

More

Less

View Lastest Price from 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 81265-93-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

SHANGHAI NOVRIBO BIOTECH

Product: 5’-O-DMT-2’-O-TBDMS-N6-Benzoyl-Adenosine 81265-93-2
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

81265-93-2, 5'-O-DMT-2'-O-TBDMS-N-Bz-AdenosineRelated Search:

2'-O-MOE-5MeU-3'-phosphoramidite N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyl-D-adenosine (N6-BENZOYL)-5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE INDEX NAME NOT YET ASSIGNED N6-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)adenosine 5'-O-DMTr-N2-isobutyrylguanosine N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine 5'-DMT-RIBO ADENOSINE (N-BZ) N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine

5'-DMT-2'-TBDMS-Bz-rA

N-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-((tert-butyldiMethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzaMide

N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-Adenosine

N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-but ldimethylsilyl)o

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine

N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsily

2'-O-TBDMS-5'-O-DMT-N6-Bz adenosine

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N6-benzoyl adenosine

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-

5'-O-DMT-2'-O-TBDMS-Bz-rA

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine

N6-Bz-2'-O-TBDMS-5'-O-DMT-adenosine

N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-adenosine

5'-O-DMTr-2'-O-TBDMS-rA(Bz)

TBS-Bz-rA

5'-O-DMT-2'-O-TBDMS-N6-benzoyladenosine

2'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl adenosine

N6-Bz-2'-O-TBDMS-5'-O-DMT-A

5'- 0 - DMT- 2 ' - 0 -TBDMS- N - Bz-Ade- nosine

TBS-rA(Bz)

81265-93-2