N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

Product Name: N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine
CAS No.: 81256-88-4
Chemical Name: N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine
Synonyms: 5'-DMT-4'-TBDMS-Bz-rA;5'-DMT-3'-TBDMS-Bz-rA;5'-O-DMT-3'-O-TBDMS-Bz-rA;N6-benzoyl-5'-O-DMT-3'-O-TBDM;N6-benzoyl-5'-O-DMT-3'-O-TBDMS-adenosine;5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine;N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine;5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N6-benzoyl-Adenosine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine;Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-
CBNumber: CB52630871
Molecular Formula: C44H49N5O7Si
Formula Weight: 787.97
MOL File: 81256-88-4.mol

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N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Property

storage temp.: 2-8°C
solubility: DMSO : 100 mg/mL (126.91 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000083614
Product name: 5'-DMT-3'-TBDMS-Bz-rA
Purity: 95+%
Packaging: 100mg
Price: $29
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB15524
Product name: N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Ark Pharm

Product number: P000083614
Product name: 5'-DMT-3'-TBDMS-Bz-rA
Purity: 95+%
Packaging: 250mg
Price: $58
Updated: 2021/12/16

Ark Pharm

Product number: P000083614
Product name: 5'-DMT-3'-TBDMS-Bz-rA
Purity: 95+%
Packaging: 1g
Price: $146
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB15524
Product name: N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
Packaging: 250mg
Price: $170
Updated: 2021/12/16

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N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Chemical Properties,Usage,Production

Uses

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.

Synthesis

129666-75-7

18162-48-6

81256-88-4

129681-71-6

Synthesis of N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide ( CAS:129681-71-6) was prepared in the following general procedure: to a mixed solution of tetrahydrofuran (THF, 800 mL) and pyridine (15 mL) of the product of the previous step (200 g, 296.9 mmol) was added, in sequence, silver cyanide (AgNCb, 83.2 g, 489.8 mmol, 1.65 eq.) and tert-butyldimethylchlorosilane ( TBSCl, 78.7 g, 522.5 mmol, 1.76 equiv). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was filtered, diluted with water (H2O, 1.0 L) and extracted with ethyl acetate (EtOAc, 3 x 1.0 L). The organic layers were combined, washed with brine (2 × 1.0 L), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel (SiO2) column chromatography with petroleum ether/ethyl acetate (3:1 to 1:1) as eluent to give the products D-2a (114 g, 145 mmol, 49% yield) and D-2b (53 g, 68 mmol, 23% yield).

References

[1] Patent: WO2018/156625, 2018, A1. Location in patent: Paragraph 0296
[2] Canadian Journal of Chemistry, 1982, vol. 60, p. 111 - 120

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Suppliers

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View Lastest Price from N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 5'-DMT-3'-TBDMS-Bz-rA 81256-88-4
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-03

81256-88-4, N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosineRelated Search:

o-Phenetidine Ceteareth-5 Sodium levothyroxine 2,2-Diphenylacetic acid 5'-O-DMTr-N2-isobutyrylguanosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 5'-DMT-RIBO ADENOSINE (N-BZ) N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

N6-benzoyl-5'-O-DMT-3'-O-TBDMS-adenosine

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

5'-DMT-3'-TBDMS-Bz-rA

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-

5'-DMT-4'-TBDMS-Bz-rA

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine

N6-benzoyl-5'-O-DMT-3'-O-TBDM

5'-O-DMT-3'-O-TBDMS-Bz-rA

5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N6-benzoyl-Adenosine

5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine

N-(9-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

N-[9-[(2R,3R,4S,5R)-5-[[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl]-4-[(tert-butyldimethylsilyl)oxy]-3-hydroxytetrahydro-2-furyl]-9H-6-purinly]benzamide

81256-88-4