6-Methyl-1,2-benzisoxazol-3(2H)-one
- Product Name
- 6-Methyl-1,2-benzisoxazol-3(2H)-one
- CAS No.
- 66571-26-4
- Chemical Name
- 6-Methyl-1,2-benzisoxazol-3(2H)-one
- Synonyms
- 6-Methyl-1,2-benzoxazol-3-one;6-Methyl-1,2-benzisoxazol-3-ol;6-Methylbenzo[d]isoxazol-3(2H);6-Methylbenzo[d]isoxazol-3(2H)-one;6-Methyl-1,2-benzisoxazol-3(2H)-one;1,2-Benzisoxazol-3(2H)-one, 6-methyl-
- CBNumber
- CB52516333
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 66571-26-4.mol
6-Methyl-1,2-benzisoxazol-3(2H)-one Property
- Melting point:
- 148-150 °C
- Density
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.66±0.20(Predicted)
- Appearance
- White to light yellow Solid
N-Bromosuccinimide Price
- Product number
- Z5011
- Product name
- 6-Methylbenzo[d]isoxazol-3(2H)-one
- Packaging
- 100mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- CHM0391447
- Product name
- 6-METHYLBENZO[D]ISOXAZOL-3(2H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.99
- Updated
- 2021/12/16
- Product number
- 119523
- Product name
- 6-Methylbenzo[d]isoxazol-3(2H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $612
- Updated
- 2021/12/16
- Product number
- 119523
- Product name
- 6-Methylbenzo[d]isoxazol-3(2H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1530
- Updated
- 2021/12/16
- Product number
- 61-6250
- Product name
- 6-methylbenzo[d]isoxazol-3(2H)-one
- Purity
- 98+%
- Packaging
- 0.25g
- Price
- $765
- Updated
- 2021/12/16
6-Methyl-1,2-benzisoxazol-3(2H)-one Chemical Properties,Usage,Production
Synthesis
158671-29-5
66571-26-4
GENERAL METHOD: N,2-Dihydroxy-4-methylbenzamide (77 mg, 0.5 mmol, 1 eq.) was dissolved in anhydrous THF (7 mL) under inert (N2) atmosphere. Triphenylphosphine (164 mg, 0.625 mmol, 1.25 eq.) was subsequently added. 2 min later, DIAD (123 μL, 0.625 mmol, 1.25 eq.) was slowly added dropwise. After 30 min of reaction, the completion of the reaction was confirmed by TLC (hexane/ethyl acetate, 1:3) monitoring. Upon completion of the reaction, THF was removed under reduced pressure.The residue was partitioned between 0.1 M NaOH solution (50 mL) and dichloromethane (100 mL). After separating the organic phase, the aqueous phase was washed three times with dichloromethane (100 mL). The organic phases were combined and the aqueous phase was acidified with 1 M HCl (10 mL) before extraction with dichloromethane (2 x 100 mL). All organic phases were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give 6-methyl-1,2-benzisoxazol-3(2H)-one.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 48, p. 5301 - 5303
[2] Patent: US2005/143434, 2005, A1. Location in patent: Page/Page column 9
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8541 - 8554
[4] Patent: EP1988085, 2008, A1. Location in patent: Page/Page column 29-30
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3357 - 3359
6-Methyl-1,2-benzisoxazol-3(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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