3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

Product Name: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
CAS No.: 491871-58-0
Chemical Name: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Synonyms: CS-1482;TCS PIM-1;SC 204330;TCS PIM-1 1;TCS PIM-1 1, >=98%;TCS PIM-1 1(sc-204330);SC 204330; TCS PIM 1-1;3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone;6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-
CBNumber: CB52518751
Molecular Formula: C18H11BrN2O2
Formula Weight: 367.2
MOL File: 491871-58-0.mol

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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Property

Boiling point:: 592.6±50.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
form: solid
pka: 6.93±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16286
Product name: TCS PIM-1 1
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 16286
Product name: TCS PIM-1 1
Purity: ≥98%
Packaging: 10mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 16286
Product name: TCS PIM-1 1
Purity: ≥98%
Packaging: 50mg
Price: $360
Updated: 2024/03/01

Cayman Chemical

Product number: 16286
Product name: TCS PIM-1 1
Purity: ≥98%
Packaging: 100mg
Price: $672
Updated: 2024/03/01

Tocris

Product number: 2979
Product name: TCSPIM-11
Purity: ≥98%(HPLC)
Packaging: 50
Price: $716
Updated: 2021/12/16

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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Chemical Properties,Usage,Production

Uses

TCS PIM-1 1 is a Pim-1 kinase inhibitor.

Definition

ChEBI: 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone is a member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively It is a pyridone, a bromophenol and a nitrile.

Biological Activity

tcs pim-1 1 is a selective inhibitor of pim-1 with ic50 value of 50 nm [1].pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. it has been shown that pim-1 over-expression is correlated with a variety of human cancers [2].tcs pim-1 1 is a potent pim-1 inhibitor and has a better selectivity to pim-1 than to pim-2. it was revealed that tcs pim-1 1 was the most potent inhibitor of pim-1 by outlining the crystal structure and it was also shown that tcs pim-1 1 had better inhibitory activity to pim-1 compared with pim-2 [1].

storage

Store at +4°C

References

[1]. cheney, i.w., et al., identification and structure-activity relationships of substituted pyridones as inhibitors of pim-1 kinase. bioorg med chem lett, 2007. 17(6): p. 1679-83.
[2]. cen, b., et al., the pim-1 protein kinase is an important regulator of met receptor tyrosine kinase levels and signaling. mol cell biol, 2014. 34(13): p. 2517-32.

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone manufacturers

Career Henan Chemical Co

Product: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone 491871-58-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

491871-58-0, 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridoneRelated Search:

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

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491871-58-0

Inhibitors