4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
- Product Name
- 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
- CAS No.
- 136647-02-4
- Chemical Name
- 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
- Synonyms
- UK-78282 HCl;UK 78282 hydrochloride;UK-78282 monohydrochloride;UK-78282 monohydrochloride >=98% (HPLC);4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-pi;4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine;4-(3,3-diphenylpropyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine h;4-(3,3-diphenylpropyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride;4-((Benzhydryloxy)Methyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine hydrochloride;4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
- CBNumber
- CB52518807
- Molecular Formula
- C29H35NO2.HCl
- Formula Weight
- 466
- MOL File
- 136647-02-4.mol
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- U3885
- Product name
- UK-78282 monohydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $180
- Updated
- 2024/03/01
- Product number
- 3829
- Product name
- UK78282hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $221
- Updated
- 2021/12/16
- Product number
- 3829
- Product name
- UK78282hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $924
- Updated
- 2021/12/16
- Product number
- U700625
- Product name
- UK78282Hydrochloride
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 257021
- Product name
- UK 78282 hydrochloride
- Packaging
- 10mg
- Price
- $502
- Updated
- 2021/12/16
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Chemical Properties,Usage,Production
Uses
UK 78282 Hydrochloride is used in the synthetic preparation of N-arylalkylpiperidine and -pyrrolidine derivatives for treating irritable bowel syndrome.
Biological Activity
UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
storage
Store at -20°C
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 832
- Advantage
- 65
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4589
- Advantage
- 55
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4999
- Advantage
- 55
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58