Atopaxar

ChemicalBook > CAS DataBase List > Atopaxar

Product Name: Atopaxar
CAS No.: 751475-53-3
Chemical Name: Atopaxar
Synonyms: E555;CS-666;E 5555;Atopaxa;Atopaxar;ER 172594-00;Atopaxar (E 5555);(943239-67-6) atopaxar;Benzoicacid,4-hydroxy-3,6-dimethoxy-;1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone
CBNumber: CB52521159
Molecular Formula: C29H38FN3O5
Formula Weight: 527.63
MOL File: 751475-53-3.mol

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Atopaxar Property

Boiling point:: 671.0±65.0 °C(Predicted)
Density: 1.22
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (473.82 mM; Need ultrasonic)
pka: 7.43±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3064
Product name: Atopaxar hydrobromide
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3064
Product name: Atopaxar hydrobromide
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $576
Updated: 2024/03/01

DC Chemicals

Product number: DC9198
Product name: Atopaxar(E5555)
Purity: >98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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Atopaxar Chemical Properties,Usage,Production

Definition

ChEBI: Atopaxar is an aromatic ketone.

Biological Activity

Atopaxar (E5555) is a potent, orally active, selective, reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. It can be used in the study of atherothrombotic diseases and interferes with platelet signaling..

in vitro

Atopaxar inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC ₅₀ of 0.019 μM. < br/> Atopaxar inhibits human platelet aggregation induced by thrombin or TRAP in a concentration-dependent manner.
Atopaxar does not inhibit PRP (platelet-rich plasma) aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to a concentration of 20 μM.

in vivo

Atopaxar (30-100 mg/kg; po) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model.
Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg.

< td class="col1 fwb"> Result:

Animal Model:	Guinea pigs, PIT model
Dosage:	Oral administration
Administration:	10 mg/kg, 30 mg/kg, 100 mg/kg
Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls.

target

PAR-1

Atopaxar Preparation Products And Raw materials

Raw materials

Preparation Products

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751475-53-3, AtopaxarRelated Search:

Diethylene Glycol Monoethyl Ether Baloxavir marboxil BAM7 Auranofin Apixaban AMG 510 ARV-771 Baloxavir

(943239-67-6) atopaxar

Atopaxar (E 5555)

CS-666

ER 172594-00

2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone

Atopaxar

E 5555

1-(3-tert-butyl-4-Methoxy-5-Morpholino-phenyl)-2-(5,6-diethoxy-7-fluoro-1-iMino-1,3-dihydro-isoindol-2-yl)-ethanone

E555

1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone

Atopaxa

Ethanone, 2-(5,6-diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]-

Benzoicacid,4-hydroxy-3,6-dimethoxy-

E5555,platelets,Atopaxar,receptor-1,signaling,PAR-1,inhibit,E-5555,Inhibitor,receptor,Protease Activated Receptor (PAR),protease-activated,atherothrombotic,E 5555,thrombin,Thrombin receptors

751475-53-3

C29H38FN3O5

Inhibitors