Baloxavir
Uses- Product Name
- Baloxavir
- CAS No.
- 1985605-59-1
- Chemical Name
- Baloxavir
- Synonyms
- (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione;S-033447;CPD2051;Baloxavir;New Baloxavir;Baloxavir (Xofluza;Baloxavir USP/EP/BP;Baloxavir Impurity 10;BXA,endonuclease,S033447,Influenza Virus;influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication
- CBNumber
- CB04662930
- Molecular Formula
- C24H19F2N3O4S
- Formula Weight
- 483.49
- MOL File
- 1985605-59-1.mol
Baloxavir Property
- Boiling point:
- 644.7±65.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM)
- form
- A solid
- pka
- 4.50±1.00(Predicted)
- CAS DataBase Reference
- 1985605-59-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0039267
- Product name
- Baloxavir
- Purity
- 98.92%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0039267
- Product name
- Baloxavir
- Purity
- 98.92%
- Packaging
- 10mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0039267
- Product name
- Baloxavir
- Purity
- 98.92%
- Packaging
- 25mg
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- CS-0039267
- Product name
- Baloxavir
- Purity
- 98.92%
- Packaging
- 50mg
- Price
- $1950
- Updated
- 2021/12/16
- Product number
- CS-0039267
- Product name
- Baloxavir
- Purity
- 98.92%
- Packaging
- 100mg
- Price
- $3000
- Updated
- 2021/12/16
Baloxavir Chemical Properties,Usage,Production
Uses
Baloxavir is a drug employed in the treatment of influenza virus infection.
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.
Uses
Baloxavir is a drug employed in the treatment of influenza virus infection.
Mechanism of action
Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.
Side effects
Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.
Baloxavir Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Baloxavir manufacturers
- Product
- Baloxavir 1985605-59-1
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-10-19
- Product
- Baloxavir 1985605-59-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-08-16
- Product
- Baloxavir 1985605-59-1
- Price
- US $25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-08-22