Baloxavir

ChemicalBook > CAS DataBase List > Baloxavir

Uses

Product Name: Baloxavir
CAS No.: 1985605-59-1
Chemical Name: Baloxavir
Synonyms: (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione;S-033447;CPD2051;Baloxavir;New Baloxavir;Baloxavir (Xofluza;Baloxavir USP/EP/BP;Baloxavir Impurity 10;BXA,endonuclease,S033447,Influenza Virus;influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication
CBNumber: CB04662930
Molecular Formula: C24H19F2N3O4S
Formula Weight: 483.49
MOL File: 1985605-59-1.mol

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Baloxavir Property

Boiling point:: 644.7±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM)
form: A solid
pka: 4.50±1.00(Predicted)
CAS DataBase Reference: 1985605-59-1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 25mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 100mg
Price: $3000
Updated: 2021/12/16

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Baloxavir Chemical Properties,Usage,Production

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.

Mechanism of action

Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.

Side effects

Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.

Baloxavir Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Baloxavir manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Baloxavir 1985605-59-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-17

PNP Biotech Co. Ltd

Product: Baloxavir 1985605-59-1
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-10-19

Hebei Yanxi Chemical Co., Ltd.

Product: Baloxavir 1985605-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-08-16

1985605-59-1, BaloxavirRelated Search:

BAM7 Auranofin Atopaxar Apixaban AMG 510 ARV-771 (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione Baloxavir marboxil Baloxavir Impurity 5 (R)-7-(benzyloxy)- 3,4,12,12a-tetrahydro- 1H-[1,4]oxazino[3,4- c]pyrido[2,1-f][1,2,4]- triazine-6,8-dione 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one

Baloxavir

CPD2051

Baloxavir Impurity 10

S-033447

New Baloxavir

1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, 12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)-

Baloxavir USP/EP/BP

(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2’4]triazine-6,8- dione

Baloxavir (Xofluza

1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione,12-[(11S)-7Chemicalbook,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-,(12aR)-

(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione

(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-9,12-dione

BXA,endonuclease,S033447,Influenza Virus

influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication

(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03?]tetradeca-10,13-diene-9,12-dione

1985605-59-1

1985605-14-1

C24H19F2N3O4S

API

1985605-59-1