Baloxavir

Uses

Product Name: Baloxavir
CAS No.: 1985605-59-1
Chemical Name: Baloxavir
Synonyms: (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione;S-033447;CPD2051;Baloxavir;Baloshavir;New Baloxavir;Baloxavir (Xofluza;Baloxavir USP/EP/BP;Baloxavir Impurity 10;BXA,endonuclease,S033447,Influenza Virus
CBNumber: CB04662930
Molecular Formula: C24H19F2N3O4S
Formula Weight: 483.49
MOL File: 1985605-59-1.mol

More

Less

Baloxavir Property

Boiling point:: 644.7±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM)
form: A solid
pka: 4.50±1.00(Predicted)
color: White to yellow
CAS DataBase Reference: 1985605-59-1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 25mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0039267
Product name: Baloxavir
Purity: 98.92%
Packaging: 100mg
Price: $3000
Updated: 2021/12/16

More

Less

Baloxavir Chemical Properties,Usage,Production

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.

Mechanism of action

Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.

Side effects

Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.

Baloxavir Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Baloxavir Suppliers

China 194 India 2 United States 7 Global 203

Yunfei Pharmaceutical(Shenzhen) Co., Ltd.

Tel: 0755-61160828 15994832653
Fax: 0755-61160828
Email: hulixiu@yunfeipharma.com
Country: China
ProdList: 248
Advantage: 58

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 310
Advantage: 61

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8126
Advantage: 58

Cangzhou Kangrui Medical Technology Co., LTD

Tel: 18632776803
Email: 355803330@qq.com
Country: China
ProdList: 554
Advantage: 58

BOYAN PHARMA

Tel: 18915538011
Email: liwei@boyanpharma.com
Country: China
ProdList: 102
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9459
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

More

Less

View Lastest Price from Baloxavir manufacturers

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: Baloxavir 1985605-59-1
Price: US $0.00-0.00/g
Min. Order: 25g
Purity: 99%
Supply Ability: 10kgs
Release date: 2024-10-18

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Baloxavir marboxil 1985605-59-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-19

Hebei Yanxi Chemical Co., Ltd.

Product: Baloxavir 1985605-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-08-16

1985605-59-1, BaloxavirRelated Search:

BAM7 Auranofin Atopaxar Apixaban AMG 510 ARV-771 (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione Baloxavir marboxil Baloxavir Impurity 5 (R)-7-(benzyloxy)- 3,4,12,12a-tetrahydro- 1H-[1,4]oxazino[3,4- c]pyrido[2,1-f][1,2,4]- triazine-6,8-dione 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one

Baloxavir

CPD2051

Baloxavir Impurity 10

S-033447

New Baloxavir

1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, 12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-, (12aR)-

Baloxavir USP/EP/BP

(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2’4]triazine-6,8- dione

Baloxavir (Xofluza

1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione,12-[(11S)-7Chemicalbook,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-,(12aR)-

(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione

(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-9,12-dione

BXA,endonuclease,S033447,Influenza Virus

influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication

(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03?]tetradeca-10,13-diene-9,12-dione

Baloshavir

1985605-59-1

1985605-14-1

C24H19F2N3O4S

API

1985605-59-1