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Iron Chelator, Dp44mT

Product Name
Iron Chelator, Dp44mT
CAS No.
152095-12-0
Chemical Name
Iron Chelator, Dp44mT
Synonyms
de44mt;Dp44mT;CS-2521;Iron Chelator;Iron Chelator, Dp44mT;Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone;2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide;2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide;2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide;Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
CBNumber
CB52524488
Molecular Formula
C14H15N5S
Formula Weight
285.37
MOL File
152095-12-0.mol
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Iron Chelator, Dp44mT Property

storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
form 
powder
color 
yellow to orange
Sensitive 
Light Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may ne stored at -20°C for 1 month.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0186
Product name
Dp44mT
Purity
≥98% (HPLC)
Packaging
5mg
Price
$79.5
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0186
Product name
Dp44mT
Purity
≥98% (HPLC)
Packaging
25mg
Price
$337
Updated
2024/03/01
Alfa Aesar
Product number
J64090
Product name
Dp44mT
Packaging
25mg
Price
$108.65
Updated
2024/03/01
Cayman Chemical
Product number
20936
Product name
Dp44mT
Purity
≥98%
Packaging
5mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
20936
Product name
Dp44mT
Purity
≥98%
Packaging
10mg
Price
$49
Updated
2024/03/01
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Iron Chelator, Dp44mT Chemical Properties,Usage,Production

Description

Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2?It displayed an average IC50?of 30 nM over 28 cancer cell lines (IC50?range was 5 nM to 400 nM).2?Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50?= 12 nM for both lines.2?The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4?It also inhibited T-cell activation and prevented CD25 up-regulation?via?a copper-dependent mechanism.5?Dp44mT has recently been shown to effectively inhibit c-Met though metalloprotease-mediated cleavage and lysosomal degradation.6

Uses

Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand.

Biochem/physiol Actions

Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.

in vivo

6 and 24 hours after the treatment with 0.1 and 1 μmol/l of dp44mt, the treatment resulted in the covalent complex formation between dna and top2α. no complex formation was found after the treatment when probed for top1 or top2β. caspase inhibitor pretreatment did not rescue the formation of top2α complex, so the formed top2α-dna complexes were not the secondary effect of apoptosis [1].

References

1) Yuan?et al.?(2004),?Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment;?Blood,?104?1450 2) Whitnall?et al.?(2006),?A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics., Proc. Natl. Acad. Sci. USA?103?14910 3) Lovejoy?et al. (2011),?Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes; Cancer Res.,?71?5871 4) Gutierrez?et al.?(2014),?The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbzone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent reduction of autophagosome synthesis and impairment of lysosomal integrity; J. Biol. Chem.,?289?33568 5) Gundelach?et al.?(2013),?The anticancer drug Dp344mT inhibits T-cell activation and CD25 through a copper-dependent mechanism; FASEB J.,?27?782 6)Park?et al. (2020),?Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding;?J. Biol.Chem.,?295?481

Iron Chelator, Dp44mT Preparation Products And Raw materials

Raw materials

Preparation Products

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Iron Chelator, Dp44mT Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
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sales@boylechem.com
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China
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VDM Biochemicals
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0330-2528181
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0330-2528171
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sales@vdmbio.com
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United States
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
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meilunui@163.com
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China
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MedChemexpress LLC
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021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
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marketing@targetmol.com
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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D&C Chemicals
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+86-21-58447131
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+86-21-61642470
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1724405207@qq.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
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4601
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View Lastest Price from Iron Chelator, Dp44mT manufacturers

Career Henan Chemical Co
Product
Iron Chelator, Dp44mT 152095-12-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

152095-12-0, Iron Chelator, Dp44mTRelated Search:


  • Iron Chelator, Dp44mT
  • 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide
  • Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
  • Dp44mT
  • de44mt
  • CS-2521
  • Iron Chelator
  • Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
  • 2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide
  • 2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide
  • 152095-12-0