(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE

Product Name: (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE
CAS No.: 54042-47-6
Chemical Name: (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE
Synonyms: 1-(4-CHLOROBENZOYL)PIPERAZINE;Methanone, (4-chlorophenyl)-1-piperazinyl-;(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE
CBNumber: CB5253201
Molecular Formula: C11H13ClN2O
Formula Weight: 224.69
MOL File: 54042-47-6.mol

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(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE Property

Melting point:: 200 °C
Boiling point:: 384.0±37.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.32±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-36

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C363570
Product name: 1-(4-Chlorobenzoyl)piperazine
Packaging: 250mg
Price: $315
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143487
Product name: (4-Chlorophenyl)(piperazin-1-yl)methanone
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143487
Product name: (4-Chlorophenyl)(piperazin-1-yl)methanone
Packaging: 5G
Price: $625
Updated: 2021/12/16

AK Scientific

Product number: 1426AL
Product name: 1-(4-Chlorobenzoyl)piperazine
Packaging: 5g
Price: $691
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0049346
Product name: (4-CHLOROPHENYL)(PIPERAZIN-1-YL)METHANONE
Purity: 95.00%
Packaging: 1G
Price: $983.52
Updated: 2021/12/16

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(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE Chemical Properties,Usage,Production

Synthesis

897445-35-1

54042-47-6

Step 2: Synthesis of (4-chlorophenyl)(piperazin-1-yl)methanone (C) Dissolve tert-butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate (26 g) in dichloromethane (350 mL). To the solution was added 4 M hydrochloric acid/dioxane solution (150 mL). The reaction mixture was stirred at room temperature for 4 hours, during which time the formation of a white precipitate was observed. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The resulting white solid was washed with ether. Subsequently, the white solid was treated with 1 N sodium hydroxide solution (200 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the target product (4-chlorophenyl)(piperazin-1-yl)methanone (17.79 g, 99% yield). Product characterization data: 1H-NMR (hydrochloride, 300 MHz, MeOD): δ 2.80-2.90 (m, 4H), 3.20-3.80 (m, 4H), 7.29-7.36 (m, 4H).

References

[1] Patent: WO2006/71875, 2006, A1. Location in patent: Page/Page column 78
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 1139 - 1148
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3739 - 3743
[4] Archiv der Pharmazie, 2017, vol. 350, # 8,
[5] Patent: CN107226807, 2017, A. Location in patent: Paragraph 0546-0548

(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE Suppliers

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54042-47-6, (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONERelated Search:

CPNQ (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE ETHYL 2-[1-(2,4-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE 4-[4-(2,4-DICHLOROBENZOYL)PIPERAZINO]-3-NITROBENZENECARBALDEHYDE O-METHYLOXIME (4-BENZOYLPIPERAZINO)(2,4-DICHLOROPHENYL)METHANONE ETHYL 2-[1-(3,4-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE 2,4-DICHLOROPHENYL 4-(5-CHLORO-2-METHYLPHENYL)PIPERAZINYL KETONE 5-[4-(4-CHLOROBENZOYL)PIPERAZINO]-6-PHENYL-3(2H)-PYRIDAZINONE BUTTPARK 39\04-51 ETHYL 2-[1-(4-CHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE (4-CHLOROPHENYL)(4-(4,6-DI(PIPERIDIN-1-YL)-1,3,5-TRIAZIN-2-YL)PIPERAZIN-1-YL)METHANONE (4-CHLOROPHENYL)[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHANONE METHYL 4-[4-(3,4-DICHLOROBENZOYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE 4-[4-(4-CHLOROBENZOYL)PIPERAZINO]BENZENECARBONITRILE 1-(p-Chlorobenzoyl)-4-isobutylpiperazine hydrochloride [4-(1,3-BENZOTHIAZOL-2-YL)PIPERAZINO](4-CHLOROPHENYL)METHANONE (4-CHLOROPHENYL)[4-(6-CHLORO-2-PYRIDINYL)PIPERAZINO]METHANONE 1-(4-chlorobenzoyl)piperazine-2,3-dicarboxylic acid

(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE

1-(4-CHLOROBENZOYL)PIPERAZINE

Methanone, (4-chlorophenyl)-1-piperazinyl-

54042-47-6