4E1RCat

Product Name: 4E1RCat
CAS No.: 328998-25-0
Chemical Name: 4E1RCat
Synonyms: 4E1RCat;CS-1228;inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid;4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid;Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
CBNumber: CB52535655
Molecular Formula: C28H18N2O6
Formula Weight: 478.45
MOL File: 328998-25-0.mol

More

Less

4E1RCat Property

Boiling point:: 764.8±60.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
pka: 4.23±0.10(Predicted)
form: powder
color: brown to dark brown

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0197
Product name: 4E1RCat
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0197
Product name: 4E1RCat
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $631
Updated: 2024/03/01

Cayman Chemical

Product number: 18399
Product name: 4E1RCat
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 18399
Product name: 4E1RCat
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 18399
Product name: 4E1RCat
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

More

Less

4E1RCat Chemical Properties,Usage,Production

Description

4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions. It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC₅₀ value of ~4 μM. 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.

Uses

4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts.

Biochem/physiol Actions

4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.

4E1RCat Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4E1RCat Suppliers

China 64 India 1 United Kingdom 1 United States 12 Global 78

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from 4E1RCat manufacturers

Career Henan Chemical Co

Product: 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid 328998-25-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

328998-25-0, 4E1RCatRelated Search:

Everolimus 4EGI-1 MK-1775 Torin 1 S3I-201 PLX4032

4E1RCat

Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-

4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid

4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid

4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid

CS-1228

inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy

4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

328998-25-0

Inhibitors