6-BROMO-TETRAL-1-ON
- Product Name
- 6-BROMO-TETRAL-1-ON
- CAS No.
- 66361-67-9
- Chemical Name
- 6-BROMO-TETRAL-1-ON
- Synonyms
- 6-Bromotetral-1-one;6-bromotetralin-1-one;6-BROMOTETRALONE;6-BROMO-A-TETRALONE;6-Bromo-1-tetralone;6-BROMO-TETRAL-1-ON;6-Bromo-1-tertralone;6-BROMO-1-TETRALONE,96%;1(2H)-Naphthalenone, 6-broMo-3,4-dihydro-
- CBNumber
- CB5254662
- Molecular Formula
- C10H9BrO
- Formula Weight
- 225.08
- MOL File
- 66361-67-9.mol
6-BROMO-TETRAL-1-ON Property
- Melting point:
- 40-42℃
- Boiling point:
- 116°C/0.05mmHg(lit.)
- Density
- 1.511±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- powder to lump
- color
- White to Orange to Green
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C10H9BrO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6H,1-3H2
- InChIKey
- OSDHOOBPMBLALZ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(Br)C=C2)CCC1
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- T263710
- Product name
- 6-BROMO-3,4-DIHYDRO-1(2H)-NAPHTHALENONE
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $113
- Updated
- 2025/07/31
- Product number
- B4841
- Product name
- 6-Bromo-1-tetralone
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- B4841
- Product name
- 6-Bromo-1-tetralone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $528
- Updated
- 2025/07/31
- Product number
- B691373
- Product name
- 6-Bromo-3,4-dihydro-2H-naphthalen-1-one
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- W7737
- Product name
- 6-Bromotetral-1-one
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
6-BROMO-TETRAL-1-ON Chemical Properties,Usage,Production
Uses
6-bromo-1-tetralone used in Wittig-Horner reaction.
Synthesis
3470-53-9
66361-67-9
The general procedure for the synthesis of 6-bromo-3,4-dihydronaphthalen-1(2H)-one from 6-amino-1,2,3,4-tetrahydro-1-naphthalenone was as follows: an aqueous solution (10 mL) of NaNO2 (2.35 g, 34 mmol) was added slowly and dropwise at 0°C to a 6-amino-1,2,3,4-tetrahydronaphthalen-1-one (5.0 g, 31 mmol) in a 25% HBr (16 mL) solution. Subsequently, the resulting suspension was transferred to a stirred mixture of 48% HBr (30 mL) of CuBr (8.9 g, 62 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. After completion of the reaction, the mixture was extracted with EtOAc and the organic phase was dried and concentrated with Na2SO4. The residue was purified by silica gel column chromatography (elution gradient: 0%-60% EtOAc/Hex) to afford 5.6 g (80% yield) of 6-bromo-3,4-dihydronaphthalen-1(2H)-one as a light yellow oil.1H NMR (400 MHz, CDCl3) δ: 2.10-2.16 (2H, m), 2.64 (2H, t, J = 6.4 Hz), 2.94 (2H, t, J = 6.0 Hz), 7.42 (1H, s), 7.44 (1H, s), 7.87 (1H, d, J = 8.9 Hz). Mass spectral analysis: [M + H]+ calculated value C10H9BrO: 225,227; measured value: 225,227.
References
[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 4, p. 391 - 396
[2] Chemistry - A European Journal, 2018, vol. 24, # 50, p. 13150 - 13157
[3] Patent: WO2018/183370, 2018, A2. Location in patent: Paragraph 00136
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 5, p. 1284 - 1304
[5] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 1, p. 130 - 151
6-BROMO-TETRAL-1-ON Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-TETRAL-1-ON manufacturers
- Product
- 6-BROMO-TETRAL-1-ON 66361-67-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-08
- Product
- 6-Bromo-3,4-dihydro-1(2H)-naphthalenone 66361-67-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 6-BROMO-TETRAL-1-ON 66361-67-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03