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GSK269962A

Product Name
GSK269962A
CAS No.
850664-21-0
Chemical Name
GSK269962A
Synonyms
CS-1126;GSK269962B;GSK 269962;GSK-269962 95%;GSK269962A(GSK269962);GSK269962 (GSK269962A);GSK269962A/GSK 269962A;ROCK inhibitor GS269962A;ROCK inhibitor GSK269962A;GSK269962A, 10 mM in DMSO
CBNumber
CB52546776
Molecular Formula
C29H30N8O5
Formula Weight
570.6
MOL File
850664-21-0.mol
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GSK269962A Property

Melting point:
125 - 127°C
Density 
1.45
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.19±0.70(Predicted)
color 
Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19180
Product name
GSK269962
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19180
Product name
GSK269962
Purity
≥95%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19180
Product name
GSK269962
Purity
≥95%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
19180
Product name
GSK269962
Purity
≥95%
Packaging
25mg
Price
$618
Updated
2024/03/01
Tocris
Product number
4009
Product name
GSK269962
Purity
≥99%(HPLC)
Packaging
10
Price
$292
Updated
2021/12/16
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GSK269962A Chemical Properties,Usage,Production

Description

Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.

Uses

GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.

in vivo

GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial[1].

Animal Model:Male Sprague-Dawley rats (350-400g)[1]
Dosage:0.3, 1, and 3 mg/kg
Administration:Oral gavage; 12 hours
Result:Induced a dose-dependent reduction in blood pressure.

IC 50

ROCK1: 1.6 nM (IC50); ROCK2: 4 nM (IC50); RSK1: 132 nM (IC50); MSK1: 49 nM (IC50); AKT1: 955 nM (IC50); AKT2: 1350 nM (IC50); AKT3: 1510 nM (IC50); CDK2: 3500 nM (IC50); GSK3α: 1260 nM (IC50)

storage

Store at +4°C

References

[1] CHRIS DOE. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 1: 89-98. DOI: 10.1124/jpet.106.110635

GSK269962A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK269962A Suppliers

China 96 India 1 The Netherlands 1 United Kingdom 1 United States 13 Global 112
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4790
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Shanghai Run-Biotech Co., Ltd.
Tel
021-57171705 13817537615
Fax
QQ3095748324
Email
sales@run-biotech.com
Country
China
ProdList
2287
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58
Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd
Tel
028-82729560 18030702676
Fax
028-82729560
Email
sales@yuehepharm.com
Country
China
ProdList
188
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58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
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View Lastest Price from GSK269962A manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
GSK269962A 850664-21-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Career Henan Chemical Co
Product
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide 850664-21-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

850664-21-0, GSK269962ARelated Search:


  • GSK 269962
  • N-[3-[[2-(4-Aminofurazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[[2-(4-morpholinyl)ethyl]oxy]benzamide
  • GSK269962A(GSK269962)
  • N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide
  • CS-1126
  • N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
  • ROCK inhibitor GS269962A
  • GSK 269962A;GSK-269962A;GSK269962;GSK 269962;GSK-269962
  • GSK269962B
  • GSK-269962 95%
  • ROCK inhibitor GSK269962A
  • GSK269962A ISO 9001：2015 REACH
  • GSK269962 (GSK269962A)
  • anti-inflammatory,ROCK,pressure,blood,antihypertensive,Rho-associated protein kinase,Inhibitor,GSK-269962,Rho-associated kinase,ROK,ROCK2,inhibit,GSK-269962A,GSK269962,vasodilatory,Rho-kinase,GSK269962A,ROCK1,cardiovascular
  • GSK269962A/GSK 269962A
  • GSK269962A, 10 mM in DMSO
  • 850664-21-0