GSK269962A
- Product Name
- GSK269962A
- CAS No.
- 850664-21-0
- Chemical Name
- GSK269962A
- Synonyms
- CS-1126;GSK269962B;GSK 269962;GSK-269962 95%;GSK269962A(GSK269962);GSK269962 (GSK269962A);GSK269962A/GSK 269962A;ROCK inhibitor GS269962A;ROCK inhibitor GSK269962A;GSK269962A ISO 9001：2015 REACH
- CBNumber
- CB52546776
- Molecular Formula
- C29H30N8O5
- Formula Weight
- 570.6
- MOL File
- 850664-21-0.mol
GSK269962A Property
- Melting point:
- 125 - 127°C
- Density
- 1.45
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.19±0.70(Predicted)
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19180
- Product name
- GSK269962
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19180
- Product name
- GSK269962
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 19180
- Product name
- GSK269962
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 19180
- Product name
- GSK269962
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- 4009
- Product name
- GSK269962
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $292
- Updated
- 2021/12/16
GSK269962A Chemical Properties,Usage,Production
Description
Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.
Uses
GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.
storage
Store at +4°C
GSK269962A Preparation Products And Raw materials
Raw materials
Preparation Products
GSK269962A Suppliers
View Lastest Price from GSK269962A manufacturers
- Product
- GSK269962A 850664-21-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- GSK269962A 850664-21-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-13
- Product
- N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide 850664-21-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01