4-Acetamidophenylboronic acid
- Product Name
- 4-Acetamidophenylboronic acid
- CAS No.
- 101251-09-6
- Chemical Name
- 4-Acetamidophenylboronic acid
- Synonyms
- 4-AcetamidophenyL;TIMTEC-BB SBB000202;4-Acetamidophenylboronicaci;P-ACETAMIDOPHENYLBORONIC ACID;4-ACETAMIDBENZENEBORONIC ACID;4-ACETAMIDOPHENYLBORONIC ACID;4-ACETAMINOPHENYLBORONIC ACID;4-ACETAMIDOBENZENEBORONIC ACID;4-ACETYLAMINOPHENYLBORONIC ACID;p-(Acetylamino)phenylboronic acid
- CBNumber
- CB5254970
- Molecular Formula
- C8H10BNO3
- Formula Weight
- 178.98
- MOL File
- 101251-09-6.mol
4-Acetamidophenylboronic acid Property
- Melting point:
- 215-220 °C (lit.)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.63±0.10(Predicted)
- form
- Powder
- color
- Gray-tan
- Water Solubility
- 85 g/L (70 ºC)
- CAS DataBase Reference
- 101251-09-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 565806
- Product name
- 4-Acetamidophenylboronic acid
- Packaging
- 1g
- Price
- $40
- Updated
- 2023/06/20
- Product number
- A3140
- Product name
- 4-Acetamidophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- A158510
- Product name
- 4-Acetamidophenylboronic acid
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 260202
- Product name
- 4-Acetamidophenyl boronic acid
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- 010749
- Product name
- 4-Acetamidobenzeneboronic acid
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
4-Acetamidophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powde
Uses
Reactant involved in:
- Synthesis of TpI2 kinase inhibitors
- Biological evaluation of modulators of survival motor neuron protein
- Cross-coupling with conjugated dienes or terminal alkenes or diazoesters
- Synthesis of tetrabutylammonium trifluoroborates
- Rhosium-catalyzed cyanation
Uses
4-Acetamidophenylboronic Acid is used in the synthesis of potent chrom-4-one inhibitors of the DNA-Dependant protein kinase for use in radiotherapy and chemotherapy in cancer treatment.
Synthesis
89415-43-0
75-36-5
101251-09-6
To a three-neck flask was added 13.7 g (0.1 mol) of 4-aminophenylboronic acid and 100 mL of trichloromethane. After thorough stirring, the reaction mixture was cooled to 5 °C and then 23.4 g (0.3 mol) of acetyl chloride was added slowly dropwise. After maintaining the reaction temperature at 5°C to complete the dropwise addition, the reaction system was warmed to 40°C and the reaction continued to be stirred for 3 hours. Upon completion of the reaction, 150 mL of water was added to the reaction mixture and the resulting solid product was washed with stirring. Subsequently, the solid was separated by filtration and washed with an appropriate amount of cold water. Finally, the resulting solid was dried in a vacuum drying oven to obtain 14 g of white or off-white solid powder 4-acetylaminophenylboronic acid in 78.2% yield.
References
[1] Patent: CN106946920, 2017, A. Location in patent: Paragraph 0017; 0018; 0020
4-Acetamidophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Acetamidophenylboronic acid manufacturers
- Product
- 4-Acetamidophenylboronic acid 101251-09-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg;100kg
- Release date
- 2019-07-03