(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine
- Product Name
- (6-(difluoroMethoxy)pyridin-3-yl)MethanaMine
- CAS No.
- 1198103-43-3
- Chemical Name
- (6-(difluoroMethoxy)pyridin-3-yl)MethanaMine
- Synonyms
- 6-(Difluoromethoxy)-3-pyridinemethanamine;3-Pyridinemethanamine, 6-(difluoromethoxy)-;(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine;(6-(Difluoromethoxy)pyridin-3-yl)methanamine - [D71646]
- CBNumber
- CB52553662
- Molecular Formula
- C7H8F2N2O
- Formula Weight
- 174.15
- MOL File
- 1198103-43-3.mol
(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Property
- Boiling point:
- 234.5±35.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.87±0.29(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D452673
- Product name
- (6-(Difluoromethoxy)pyridin-3-yl)methanamine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC201048
- Product name
- (6-(Difluoromethoxy)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- HCH0368056
- Product name
- (6-(DIFLUOROMETHOXY)PYRIDIN-3-YL)METHANAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.16
- Updated
- 2021/12/16
- Product number
- CM175071
- Product name
- (6-(Difluoromethoxy)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $443
- Updated
- 2021/12/16
- Product number
- CD11333940
- Product name
- (6-(Difluoromethoxy)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $469
- Updated
- 2021/12/16
(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Chemical Properties,Usage,Production
Synthesis
1198103-42-2
1198103-43-3
General procedure for the synthesis of 6-(difluoromethoxy)pyridine-3-carbonitrile from 6-(difluoromethoxy)pyridine-3-methanamine: Raney nickel (150 mg) was added to a solution of 6-(difluoromethoxy)nicotinonitrile (0.541 g, 3.18 mmol) in methanol (20 mL, saturated with ammonia). The reaction mixture was hydrogenated at room temperature under 45 psi hydrogen pressure for 20 hours. Upon completion of the reaction, the reaction mixture was filtered through a short bed of diatomaceous earth and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography using dichloromethane:methanol=90:10 as eluent to afford 6-difluoromethoxypyridine-3-methanamine as a light yellow oil in a yield of 440 mg (80% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.12 (d, 1H), 7.73 (dd, 1H), 7.45 (t, 1H), 6.88 (d, 1H), 3.88 (s, 2H) (NH2 not shown); 19F NMR (400 MHz, CDCl3) δ -88.98 and -89.17; MS ( ESI) m/z 175 [M + H]+.
References
[1] Patent: WO2009/145720, 2009, A1. Location in patent: Page/Page column 29
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6866 - 6880
(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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