ChemicalBook > CAS DataBase List > A-674563

A-674563

Product Name
A-674563
CAS No.
552325-73-2
Chemical Name
A-674563
Synonyms
CS-258;A-674563;A-674563 /A674563;A-674563 USP/EP/BP;A-674563;A 674563; A674563;A-674563 Akt1 Inhibitor A-674563;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;(2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine
CBNumber
CB52561454
Molecular Formula
C22H22N4O
Formula Weight
358.44
MOL File
552325-73-2.mol
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A-674563 Property

Boiling point:
624.4±55.0 °C(Predicted)
Density 
1.229
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; ≥23.8 mg/mL in H2O; ≥4.9 mg/mL in DMSO
form 
solid
pka
13.43±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18715
Product name
A-674563
Purity
≥95%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
18715
Product name
A-674563
Purity
≥95%
Packaging
1mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
18715
Product name
A-674563
Purity
≥95%
Packaging
5mg
Price
$333
Updated
2024/03/01
Cayman Chemical
Product number
18715
Product name
A-674563
Purity
≥95%
Packaging
10mg
Price
$570
Updated
2024/03/01
Usbiological
Product number
349624
Product name
A-674563
Packaging
500ug
Price
$265
Updated
2021/12/16
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A-674563 Chemical Properties,Usage,Production

Uses

A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively.

Biological Activity

a-674563 is a potent and selective akt1 inhibitor with ic50 value of 14 nm. a-67453 also inhibited pka and cdk2 with ic50 value of 16 nm and 46 nm.akt, also known as protein kinase b, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.in miapaca-2 cells treated with a-674563 for 48 hour, it slowed the tumor cell proliferation (ec50 = 0.4 μm). in sts cells, phosphorylation of gsk3 and mdm2 was prominently reduced by a-674563 treatment. [1] akt inhibition-induced g2 cells cycle arrest and apoptosis were also observed in a563-treated sts cells. [2]in scid mice carrying established pc-3 tumors, administration of a-674563 at 40 mg/kg per day for 21 days, combined with administration of paclitaxel at 15 mg/kg per day on days 20.24.28, increased the efficacy of paclitaxel compared with paclitaxel monotherapy. [1] a563 also significantly blocked ht1080 xenograft growth in nude mice. [2]

target

Akt1

References

1. luo y, shoemaker ar, liu x et al. potent and selective inhibitors of akt kinases slow the progress of tumors in vivo. mol cancer ther. 2005 jun;4(6):977-86.2. zhu qs, ren w, korchin b et al. soft tissue sarcoma cells are highly sensitive to akt blockade: a role for p53-independent up-regulation of gadd45 alpha. cancer res. 2008 apr 15;68(8):2895-903.

A-674563 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-674563 Suppliers

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View Lastest Price from A-674563 manufacturers

Career Henan Chemical Co
Product
A-674563 552325-73-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

552325-73-2, A-674563Related Search:

4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol CCT128930 Y27632 (hydrochloride) MK-2206 2HCl Rapamycin PLX4032

  • A-674563
  • (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine
  • A-674563 /A674563
  • (2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
  • (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563
  • A-674563 (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563 /A674563
  • A-674563;A 674563; A674563
  • (S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
  • CS-258
  • Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-
  • A-674563 USP/EP/BP
  • A-674563 Akt1 Inhibitor A-674563
  • 552325-73-2
  • Akt
  • mTOR
  • PI3K
  • Inhibitors