Refametinib

Product Name: Refametinib
CAS No.: 923032-37-5
Chemical Name: Refametinib
Synonyms: CS-2434;RDEA119;BAY-869766;RefaMetinib;BAY 8697661;RDEA119 USP/EP/BP;REFAMETINIB(RDEA119);RDEA-119 (BAY-869766);Acrylamide Impurity 13;BAY 869766; BAY 86-9766
CBNumber: CB52561494
Molecular Formula: C19H20F3IN2O5S
Formula Weight: 572.34
MOL File: 923032-37-5.mol

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Refametinib Property

Boiling point:: 566.9±60.0 °C(Predicted)
Density: 1.82±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form: Powder
pka: 15.54±0.20(Predicted)

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16997
Product name: Refametinib
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 16997
Product name: Refametinib
Purity: ≥95%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 16997
Product name: Refametinib
Purity: ≥95%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 16997
Product name: Refametinib
Purity: ≥95%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

Usbiological

Product number: 464562
Product name: Refametinib
Packaging: 1mg
Price: $312
Updated: 2021/12/16

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Refametinib Chemical Properties,Usage,Production

Description

Lorlatinib (PF-06463922, Pfizer Oncology, Groton, CT, USA) is an oral TKI that targets both ALK and ROS1 with high affinity and good CNS penetration [91].

Uses

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2. Potent MEK inhibitor.

Clinical Use

Lorlatinib is the sole third-generation ALK inhibitor at this time; it is approved for ALK-positive NSCLC patients who progressed on at least two ALK inhibitors with one being crizotinib or who progressed on alectinib or ceritinib if either is used in the frontline setting.

target

MEK1

References

[1] iverson c, larson g, lai c, et al. rdea119/bay 869766: a potent, selective, allosteric inhibitor of mek1/2 for the treatment of cancer. cancer research, 2009, 69(17): 6839-6847.

Refametinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Refametinib Suppliers

China 87 India 3 United Kingdom 2 United States 14 Global 106

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

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View Lastest Price from Refametinib manufacturers

Hebei Duling International Trade Co. LTD

Product: RDEA119 923032-37-5
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-03-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: Refametinib 923032-37-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Refametinib 923032-37-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

923032-37-5, Refametinib Related Search:

Bortezomib MK-1775 Temsirolimus PD 0332991 HCl Rapamycin Olaparib

RDEA119

BAY-869766

RefaMetinib

RDEA-119 (BAY-869766)

BAY 8697661

RefaMetinib/BAY 8697661

N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide

(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

REFAMETINIB(RDEA119)

CS-2434

BAY 869766; BAY 86-9766

Refametinib (BAY86-9766)

N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide

BAY 869766;BAY 86-97661;RDEA119

Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]-

RDEA119 USP/EP/BP

Refametinib S enantiomer

Acrylamide Impurity 13

923032-37-5

C19H20F3IN2O5S

Inhibitors