Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-
- Product Name
- Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-
- CAS No.
- 362665-56-3
- Chemical Name
- Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-
- Synonyms
- Tilolison;Pitolisomt;PITOLISANT;Tirolisant;Tiprolisant;Pitolisant (BF2.649);Tiprolisant Pitolisant;TIPROLISANT;BF-2649;BF 2.649;Chlorophenyl)propoxy)propyl)piperidine;3-(4-Chlorophenyl)propyl 3-piperidinopropyl ether
- CBNumber
- CB52563438
- Molecular Formula
- C17H26ClNO
- Formula Weight
- 295.85
- MOL File
- 362665-56-3.mol
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]- Property
- Boiling point:
- 398.7±32.0 °C(Predicted)
- Density
- 1.056
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO
- form
- Powder
- pka
- 9.41±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FP168175
- Product name
- Pitolisant
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FP168175
- Product name
- Pitolisant
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FP168175
- Product name
- Pitolisant
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- orb611361
- Product name
- Pitolisant
- Packaging
- 100mg
- Price
- $606.9
- Updated
- 2021/12/16
- Product number
- FP168175
- Product name
- Pitolisant
- Packaging
- 500mg
- Price
- $650
- Updated
- 2021/12/16
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]- Chemical Properties,Usage,Production
Uses
Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor. Pitolisant is also used in the treatment of patients with narcolepsy, excessive daytime sleepiness, cataplexy, disturbed nocturnal sleep, hypnagogic hallucinations and sleep paralysis
Definition
ChEBI: Pitolisant is an organochlorine compound.
in vivo
The administration of Pitolisantat a single dose of 10 mg/kg 30 min before a single dose of Olanzapine (2 mg/kg b.w.) also significantly affects immobility time in the FST. Subsequent administration of the aforementioned drug sequence in mice statistically significantly increases the duration of immobility in comparison to the time determined in the control group in the FST. It decreased locomotor activity as well. In contrast, the results obtained in subchronic treatment after fifteen administrations of both drugs (Pitolisant 10 mg/kg b.w., and after 30 min Olanzapine 2 mg/kg b.w., and again after 4 h Olanzapine 2 mg/kg b.w.) show that the administration of Pitolisant followed by that of Olanzapine equalized the locomotor activity in mice; in comparison to the level of motility in the control group, to which only Pitolisant is administered. More importantly, this combination of drugs significantly reduces immobility time to the level obtained in the control group in the forced swim test in mice [one-way ANOVA; F (3,20)=4.226,P=0.0181][2]. Rats given Pitolisant (10 mg/kg) during the conditioning phase stayed 502±94 s on the paired texture, a value not statistically different from that of controls, indicating that Pitolisant did not support place preference[3].
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]- manufacturers
- Product
- Pitolisant 362665-56-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Pitolisant 362665-56-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]- 362665-56-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31