1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
- Product Name
- 1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
- CAS No.
- 216076-11-8
- Chemical Name
- 1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
- Synonyms
- 1-(2-chlorophenyl)-2-(4-pyridyl)ethanone;1-(2-chlorophenyl)-2-(4-pyridinyl)Ethanone;1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE;Ethanone, 1-(2-chlorophenyl)-2-(4-pyridinyl)-
- CBNumber
- CB5257148
- Molecular Formula
- C13H10ClNO
- Formula Weight
- 231.68
- MOL File
- 216076-11-8.mol
1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE Property
- storage temp.
- Inert atmosphere,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9402AH
- Product name
- 1-(2-Chloro-phenyl)-2-pyridin-4-yl-ethanone
- Packaging
- 250mg
- Price
- $401
- Updated
- 2021/12/16
- Product number
- HCH0314147
- Product name
- 1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $496.46
- Updated
- 2021/12/16
- Product number
- CM171381
- Product name
- 1-(2-Chloro-phenyl)-2-pyridin-4-yl-ethanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $608
- Updated
- 2021/12/16
- Product number
- 216076118
- Product name
- 1-(2-Chlorophenyl)-2-(pyridin-4-yl)ethanone
- Packaging
- 1g
- Price
- $630.5
- Updated
- 2021/12/16
- Product number
- CD11165230
- Product name
- 1-(2-Chlorophenyl)-2-(pyridin-4-yl)ethanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $644
- Updated
- 2021/12/16
1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE Chemical Properties,Usage,Production
Synthesis
108-89-4
289686-74-4
216076-11-8
1. A solution of 4-methylpyridine (1.07 g, 11.5 mmol) in THF (10.0 mL) was added slowly and dropwise to a solution of tetrahydrofuran (THF, 20.0 mL) containing lithium diisopropylammonium (6.5 mL, 1.6 M in cyclohexane, 10.4 mmol) at -78°C. 2. The dry ice bath was removed and the reaction mixture was stirred at 0 °C for 30 min and then re-cooled to -78 °C. 3. A solution of 2-chloro-N-methoxy-N-methylbenzamide (2.39 g, 12 mmol) in THF (10.0 mL) was added dropwise to the reaction mixture. 4. The reaction mixture was gradually warmed to room temperature and stirred overnight. 5. The resulting white solid was collected by filtration and dissolved in ethyl acetate. 6. The organic phase was washed sequentially with water and brine and then dried with anhydrous magnesium sulfate. 7. Vacuum concentration of the dried organic phase afforded the target product 1-(2-chlorophenyl)-2-(pyridin-4-yl)ethanone (1.09 g, 4.7 mmol, 47% yield) as a white solid.
References
[1] Patent: WO2009/91759, 2009, A1. Location in patent: Page/Page column 49
[2] Patent: WO2009/91760, 2009, A1. Location in patent: Page/Page column 41
1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE Suppliers
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