ATN-224
- Product Name
- ATN-224
- CAS No.
- 649749-10-0
- Chemical Name
- ATN-224
- Synonyms
- ATN-224;WTX-101);ATN 224,ATN224;Choline tetrathiomolybdate;Bis(choline)tetrathioMolybdate;ATN-224 (Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
- CBNumber
- CB52582927
- Molecular Formula
- C5H14MoNOS4-
- Formula Weight
- 328.36
- MOL File
- 649749-10-0.mol
ATN-224 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM) - form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3409
- Product name
- ATN-224
- Purity
- ≥95% (elemental analysis)
- Packaging
- 5MG
- Price
- $81
- Updated
- 2024/03/01
- Product number
- SML3409
- Product name
- ATN-224
- Purity
- ≥95% (elemental analysis)
- Packaging
- 25MG
- Price
- $327
- Updated
- 2024/03/01
- Product number
- 23553
- Product name
- ATN-224
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 23553
- Product name
- ATN-224
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 23553
- Product name
- ATN-224
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $365
- Updated
- 2024/03/01
ATN-224 Chemical Properties,Usage,Production
Description
ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).
ATN-224 Preparation Products And Raw materials
Raw materials
Preparation Products
ATN-224 Suppliers
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