ATN-224

Product Name: ATN-224
CAS No.: 649749-10-0
Chemical Name: ATN-224
Synonyms: ATN-224;WTX-101);ATN 224,ATN224;ATN-224, 10 mM in DMSO;Choline tetrathiomolybdate;Bis(choline)tetrathioMolybdate;ATN-224 (Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
CBNumber: CB52582927
Molecular Formula: C5H14MoNOS4-
Formula Weight: 328.36
MOL File: 649749-10-0.mol

More

Less

ATN-224 Property

storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM)
form: A crystalline solid
color: Pink to red
Water Solubility: H2O: ≥0.1mg/mL, clear

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3409
Product name: ATN-224
Purity: ≥95% (elemental analysis)
Packaging: 5MG
Price: $79.13
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3409
Product name: ATN-224
Purity: ≥95% (elemental analysis)
Packaging: 25MG
Price: $336
Updated: 2025/07/31

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 5mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 10mg
Price: $365
Updated: 2024/03/01

More

Less

ATN-224 Chemical Properties,Usage,Production

Description

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC₅₀s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC₅₀s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC₅₀s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC₅₀s = 1.50-3 mg/kg via gavage).

Uses

ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5±3.7 nM.

in vivo

ATN-224 also significantly (P<0.05) inhibits angiogenesis in the Matrigel plug model in mice either when added directly to the plug or when given by oral gavage. Inhibition of angiogenesis when ATN-224 is given by oral gavage occurred before there is measurable depletion of copper in either plasma or copper from the Matrigel plug. This result shows that ATN-224 inhibits angiogenesis independently of copper depletion^[1].

References

[1] Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DOI:10.1158/1078-0432.CCR-06-0171
[2] Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-na?ve prostate cancer. Urol Oncol. 2013 Jul;31(5):581-8. DOI:10.1016/j.urolonc.2011.04.009

ATN-224 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ATN-224 Suppliers

China 47 India 1 United Kingdom 1 United States 6 Global 55

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Changsha Jing Kang New Material Technology Co., Ltd.

Tel: 0733-0731-85118349 18874718518
Fax: 0731-85118349
Email: 877634463@qq.com
Country: China
ProdList: 1864
Advantage: 50

Lanzhou Angeli Biochemical Technology Co., Ltd.

Tel: 0931-8235634 13321316780
Fax: +86(931) 4873122
Email: 1455540579@qq.com
Country: China
ProdList: 958
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

649749-10-0, ATN-224Related Search:

ATN-224

Bis(choline)tetrathioMolybdate

ATN-224 (Choline tetrathiomolybdate

WTX-101)

Choline tetrathiomolybdate

CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101

bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide

2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate

ATN 224,ATN224

ATN-224, 10 mM in DMSO

649749-10-0

2C5H14NOMoS4

C10H32MoN2O2S4

1