ChemicalBook > CAS DataBase List > ATN-224

ATN-224

Product Name
ATN-224
CAS No.
649749-10-0
Chemical Name
ATN-224
Synonyms
ATN-224;WTX-101);ATN 224,ATN224;Choline tetrathiomolybdate;Bis(choline)tetrathioMolybdate;ATN-224 (Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
CBNumber
CB52582927
Molecular Formula
C5H14MoNOS4-
Formula Weight
328.36
MOL File
649749-10-0.mol
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ATN-224 Property

storage temp. 
Store at -20°C
solubility 
DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM)
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3409
Product name
ATN-224
Purity
≥95% (elemental analysis)
Packaging
5MG
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3409
Product name
ATN-224
Purity
≥95% (elemental analysis)
Packaging
25MG
Price
$327
Updated
2024/03/01
Cayman Chemical
Product number
23553
Product name
ATN-224
Purity
≥95%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
23553
Product name
ATN-224
Purity
≥95%
Packaging
5mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
23553
Product name
ATN-224
Purity
≥95%
Packaging
10mg
Price
$365
Updated
2024/03/01
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ATN-224 Chemical Properties,Usage,Production

Description

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).

ATN-224 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATN-224 Suppliers

China 28 India 1 United Kingdom 1 United States 4 Global 34
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58

649749-10-0, ATN-224Related Search:


  • ATN-224
  • Bis(choline)tetrathioMolybdate
  • ATN-224 (Choline tetrathiomolybdate
  • WTX-101)
  • Choline tetrathiomolybdate
  • CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101
  • bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
  • 2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate
  • ATN 224,ATN224
  • 649749-10-0
  • 2C5H14NOMoS4
  • C10H32MoN2O2S4