3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one

Product Name: 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one
CAS No.: 122080-99-3
Chemical Name: 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one
Synonyms: 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one;Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One;3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one;3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one;3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one;3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]-
CBNumber: CB52597864
Molecular Formula: C13H15NO3S
Formula Weight: 265.33
MOL File: 122080-99-3.mol

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3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Property

Boiling point:: 437.5±55.0 °C(Predicted)
Density: 1.351±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: -5.91±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T560003
Product name: 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
Packaging: 100mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077592
Product name: 3-TOSYL-3-AZA-BICYCLO[3.2.0]HEPTAN-6-ONE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Matrix Scientific

Product number: 119683
Product name: 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
Purity: 95+%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

Matrix Scientific

Product number: 119683
Product name: 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
Purity: 95+%
Packaging: 1g
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077592
Product name: 3-TOSYL-3-AZA-BICYCLO[3.2.0]HEPTAN-6-ONE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

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3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Chemical Properties,Usage,Production

Synthesis

122080-91-5

122080-99-3

A 1,2-dichloroethane (250 mL) solution of Compound 6 (35 g, 0.10 mol) was slowly added dropwise over 20 minutes to a 1,2-dichloroethane (100 mL) solution of trifluoromethanesulfonic anhydride (58 g, 0.20 mol). Subsequently, a 1,2-dichloroethane (100 mL) solution of colistin (19 g, 0.15 mol) was added slowly over 30 minutes. The reaction mixture was heated to 90 °C and stirred for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated. The residue was hydrolyzed in the two-phase system H2O-CCl4. The organic layer was separated, dried with anhydrous Na2SO4, filtered and the filtrate evaporated to remove the solvent. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10/1) to afford compound 7 (15 g, 54% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 2.67-2.72 (m, 1H), 2.85-2.92 (m, 1H), 2.94-3.00 (m, 2H), 3.27-3.35 (m, 1H), 3.59-3.66 (m, 2H), 3.17-3.12 (m, 2H), 3.83-3.86 (d, J=10Hz, 1H), 7.34-7.36 (d, J=8Hz, 2H), 7.69-7.71 (d, J=8.4Hz, 2H); MS calculated values: 265; MS measured value: 266 ([M+H]+).

References

[1] Patent: WO2015/38661, 2015, A1. Location in patent: Paragraph 0139

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Preparation Products And Raw materials

Raw materials

Preparation Products

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122080-99-3, 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-oneRelated Search:

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one

3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one

3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one

Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One

3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one

3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]-

122080-99-3