3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one
- Product Name
- 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one
- CAS No.
- 122080-99-3
- Chemical Name
- 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one
- Synonyms
- 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one;Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One;3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one;3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one;3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one;3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]-
- CBNumber
- CB52597864
- Molecular Formula
- C13H15NO3S
- Formula Weight
- 265.33
- MOL File
- 122080-99-3.mol
3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Property
- Boiling point:
- 437.5±55.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -5.91±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T560003
- Product name
- 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0077592
- Product name
- 3-TOSYL-3-AZA-BICYCLO[3.2.0]HEPTAN-6-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- 119683
- Product name
- 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 119683
- Product name
- 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CHM0077592
- Product name
- 3-TOSYL-3-AZA-BICYCLO[3.2.0]HEPTAN-6-ONE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Chemical Properties,Usage,Production
Synthesis
122080-91-5
122080-99-3
A 1,2-dichloroethane (250 mL) solution of Compound 6 (35 g, 0.10 mol) was slowly added dropwise over 20 minutes to a 1,2-dichloroethane (100 mL) solution of trifluoromethanesulfonic anhydride (58 g, 0.20 mol). Subsequently, a 1,2-dichloroethane (100 mL) solution of colistin (19 g, 0.15 mol) was added slowly over 30 minutes. The reaction mixture was heated to 90 °C and stirred for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated. The residue was hydrolyzed in the two-phase system H2O-CCl4. The organic layer was separated, dried with anhydrous Na2SO4, filtered and the filtrate evaporated to remove the solvent. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10/1) to afford compound 7 (15 g, 54% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 2.67-2.72 (m, 1H), 2.85-2.92 (m, 1H), 2.94-3.00 (m, 2H), 3.27-3.35 (m, 1H), 3.59-3.66 (m, 2H), 3.17-3.12 (m, 2H), 3.83-3.86 (d, J=10Hz, 1H), 7.34-7.36 (d, J=8Hz, 2H), 7.69-7.71 (d, J=8.4Hz, 2H); MS calculated values: 265; MS measured value: 266 ([M+H]+).
References
[1] Patent: WO2015/38661, 2015, A1. Location in patent: Paragraph 0139
3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Suppliers
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