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MK 0343

Product Name
MK 0343
CAS No.
233275-76-8
Chemical Name
MK 0343
Synonyms
MK 0343;MRK-409;MK0343,MK 0343;MK-0343 >=98% (HPLC);7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine;7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine, 7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-Methyl-1H-1,2,4-triazol-5-yl)Methoxy]-
CBNumber
CB52603000
Molecular Formula
C19H17F2N7O
Formula Weight
397.38
MOL File
233275-76-8.mol
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MK 0343 Property

Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
2.11±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0565
Product name
MK-0343
Purity
≥98% (HPLC)
Packaging
25mg
Price
$525
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0565
Product name
MK-0343
Purity
≥98% (HPLC)
Packaging
5mg
Price
$133
Updated
2022/05/15
Tocris
Product number
4415
Product name
MK0343
Purity
≥99%(HPLC)
Packaging
10
Price
$250
Updated
2021/12/16
Tocris
Product number
4415
Product name
MK0343
Purity
≥99%(HPLC)
Packaging
50
Price
$900
Updated
2021/12/16
TRC
Product number
M425143
Product name
MK0343
Packaging
1mg
Price
$110
Updated
2021/12/16
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MK 0343 Chemical Properties,Usage,Production

Uses

MK 0343 is a subtype-selective partial GABAA receptor agonist with the ability to cause anxiolytic and non-sedating properties.

Biological Activity

MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.

in vivo

MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [3H]flumazenil binding assay, with an Occ50 of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL[1].

Animal Model:Male Sprague-Dawley rats (approximately 250–300g) (pharmacokinetics)[1]
Dosage:1, 2 or 3?mg/kg
Administration:Oral administration
Result:Readily penetrated the brain in rats and occupies the benzodiazepine site of GABAA receptors, with an Occ50 of 2.2?mg/kg p.o. and a corresponding plasma EC50 of 115?ng/mL.

MK 0343 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK 0343 Suppliers

China 36 India 1 United Kingdom 1 United States 8 Global 46
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Chengdu Feibai Pharmaceutical Co., Ltd.
Tel
028-84641798 18782128315
Email
3302391190@qq.com
Country
China
ProdList
9799
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58

233275-76-8, MK 0343Related Search:


  • MK 0343
  • 1,2,4-Triazolo[4,3-b]pyridazine, 7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-Methyl-1H-1,2,4-triazol-5-yl)Methoxy]-
  • 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
  • MRK-409
  • 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine
  • MK-0343 >=98% (HPLC)
  • MK0343,MK 0343
  • 233275-76-8
  • 233275-76-9
  • C19H17F2N7O