ETHANONE, 2-BROMO-1-CYCLOPROPYL-
- Product Name
- ETHANONE, 2-BROMO-1-CYCLOPROPYL-
- CAS No.
- 69267-75-0
- Chemical Name
- ETHANONE, 2-BROMO-1-CYCLOPROPYL-
- Synonyms
- 2-Bromo-1-cyclopropylethan-1-one;Bromoacetylcyclopropane;Cyclopropylbromomethylketone;Bromomethyl cyclopropylketone;2-bromo-1-cyclopropyl ethenone;2-BROMO-1-CYCLOPROPYL ETHANONE;2-Bromomethyl Cyclopropylketone;2-Bromo-1-Cycloproplyethan-1-One;1-bromomethyl cyclopropyl ketone;ETHANONE, 2-BROMO-1-CYCLOPROPYL-
- CBNumber
- CB5260627
- Molecular Formula
- C5H7BrO
- Formula Weight
- 163.01
- MOL File
- 69267-75-0.mol
ETHANONE, 2-BROMO-1-CYCLOPROPYL- Property
- Boiling point:
- 60-65 °C(Press: 10 Torr)
- Density
- 1.669
- refractive index
- 1.543
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform, Ethyl Acetate (Slightly)
- form
- Liquid
- color
- Clear Colourless
- InChI
- 1S/C5H7BrO/c6-3-5(7)4-1-2-4/h4H,1-3H2
- InChIKey
- WCCCDMWRBVVYCQ-UHFFFAOYSA-N
- SMILES
- O=C(C1CC1)CBr
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- TMT00623
- Product name
- 2-Bromo-1-cyclopropylethanone
- Packaging
- 1g
- Price
- $550
- Updated
- 2025/07/31
- Product number
- B6077
- Product name
- 2-Bromo-1-cyclopropylethanone
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $51
- Updated
- 2025/07/31
- Product number
- B6077
- Product name
- 2-Bromo-1-cyclopropylethanone
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $156
- Updated
- 2025/07/31
- Product number
- B682710
- Product name
- 2-Bromo-1-cyclopropylethanone
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B682710
- Product name
- 2-Bromo-1-cyclopropylethanone
- Packaging
- 5g
- Price
- $115
- Updated
- 2021/12/16
ETHANONE, 2-BROMO-1-CYCLOPROPYL- Chemical Properties,Usage,Production
Uses
2-Bromo-1-cyclopropylethanone is an intermediate used to prepare pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. It is also used to synthesize indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line.
Synthesis
765-43-5
69267-75-0
The general procedure for the synthesis of 1-cyclopropyl-2-bromoacetophenone from cyclopropylmethyl ketone was as follows: a methanol (MeOH, 100 mL) solution of cyclopropylmethyl ketone (20.7 mL, 220 mmol) was treated with bromine (11.3 mL, 220 mmol) at -5 °C and the reaction lasted for 2 hours. Subsequently, 50 mL of water was added to the reaction mixture and the reaction system was slowly warmed to room temperature and left to stand overnight. After completion of the reaction, the mixture was diluted with 150 mL of water and extracted with ether. The organic phase was separated, washed with sodium bicarbonate (NaHCO3) solution, dried over anhydrous sodium sulfate (Na2SO4), and concentrated to remove the solvent to give the light yellow oily product 1-cyclopropyl-2-bromoacetophenone (35 g, 99% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 0.91-1.02 (m, 2H), 1.03-1.16 (m, 2H), 2.08-2.20 (m, 1H), 4.02 (s, 2H).
References
[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 22
[2] Patent: WO2013/184734, 2013, A1. Location in patent: Paragraph 00299; 00300
[3] Synlett, 2010, # 6, p. 873 - 876
[4] Patent: WO2010/96395, 2010, A1. Location in patent: Page/Page column 34
[5] Patent: WO2015/76800, 2015, A1. Location in patent: Page/Page column 318
ETHANONE, 2-BROMO-1-CYCLOPROPYL- Preparation Products And Raw materials
Raw materials
Preparation Products
ETHANONE, 2-BROMO-1-CYCLOPROPYL- Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11032
- Advantage
- 64
- Tel
- 025-83697070 13913916777;
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15724
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- +86 (25) 5860-8846
- Fax
- +86 (25) 5860-8846
- kt_chem@126.com
- Country
- China
- ProdList
- 218
- Advantage
- 62
- Tel
- +86 (21) 5196-9732
- Fax
- +86 (21) 5196-9733
- Country
- China
- ProdList
- 996
- Advantage
- 57
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9519
- Advantage
- 58
View Lastest Price from ETHANONE, 2-BROMO-1-CYCLOPROPYL- manufacturers
- Product
- ETHANONE, 2-BROMO-1-CYCLOPROPYL- 69267-75-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 2000
- Release date
- 2025-06-11
- Product
- ETHANONE, 2-BROMO-1-CYCLOPROPYL- 69267-75-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24