ChemicalBook > CAS DataBase List > 2-broMo-5-Methylpyridine-1-o×ide

2-broMo-5-Methylpyridine-1-o×ide

Product Name
2-broMo-5-Methylpyridine-1-o×ide
CAS No.
19230-58-1
Chemical Name
2-broMo-5-Methylpyridine-1-o×ide
Synonyms
2-bromo-5-methylpyridine N-oxide;2-broMo-5-Methylpyridine-1-o×ide;Pyridine, 2-broMo-5-Methyl-, 1-oxide;2-bromo-5-methyl-1-oxidopyridin-1-ium;2-Bromo-5-methylpyridin-1-ium-1-olate
CBNumber
CB52614141
Molecular Formula
C6H6BrNO
Formula Weight
188.02
MOL File
19230-58-1.mol
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2-broMo-5-Methylpyridine-1-o×ide Property

Melting point:
246-248 °C
Boiling point:
345.7±22.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-0.52±0.10(Predicted)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B808165
Product name
2-Bromo-5-methylpyridine1-Oxide
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143541
Product name
2-Bromo-5-methylpyridine 1-oxide
Packaging
500mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143541
Product name
2-Bromo-5-methylpyridine 1-oxide
Packaging
1g
Price
$158
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0360952
Product name
2-BROMO-5-METHYLPYRIDINE 1-OXIDE
Purity
95.00%
Packaging
250MG
Price
$197.4
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143541
Product name
2-Bromo-5-methylpyridine 1-oxide
Packaging
2g
Price
$275
Updated
2021/12/16
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2-broMo-5-Methylpyridine-1-o×ide Chemical Properties,Usage,Production

Synthesis

3510-66-5

19230-58-1

The general procedure for the synthesis of 2-bromo-5-methylpyridine nitrogen oxides from 2-bromo-5-methylpyridine was as follows: 2-bromo-5-methylpyridine (4 g, 2.3 mmol) was dissolved in dichloromethane (500 mL) at 0 °C and m-CPBA (52 g, 304 mmol) was added slowly. The reaction mixture was stirred continuously at room temperature for 20 hours. Upon completion of the reaction, the pH was adjusted with saturated K2CO3 solution to about 9. The organic layer was separated and concentrated to give the crude product. The crude product was purified by fast silica gel column chromatography with petroleum ether/ethyl acetate (1:1, v/v) as eluent to afford the target compound 2-bromo-5-methylpyridine 1-oxide (33 g, 75% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 8.25 (s, 1H), 8.75 (d, 1H, J = 8.4 Hz), 6.95-6.94 (m, 1H), 2.30 (s, 3H).

References

[1] Patent: WO2011/146287, 2011, A1. Location in patent: Page/Page column 29-30
[2] Patent: WO2017/35353, 2017, A1. Location in patent: Paragraph 0911
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 16, p. 7126 - 7135
[4] Journal of Organic Chemistry, 2009, vol. 74, # 2, p. 939 - 942

2-broMo-5-Methylpyridine-1-o×ide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-broMo-5-Methylpyridine-1-o×ide Suppliers

China 38 India 5 United Kingdom 2 United States 3 Global 48
Pure Chemistry Scientific Inc.
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Nanijing m&m biotechnology Co. ,Ltd.
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Hangzhou Molcore Biopharmatech Co.,Ltd
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19230-58-1, 2-broMo-5-Methylpyridine-1-o×ideRelated Search:

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  • 2-Bromo-5-methylpyridin-1-ium-1-olate
  • Pyridine, 2-broMo-5-Methyl-, 1-oxide
  • 2-bromo-5-methyl-1-oxidopyridin-1-ium
  • 2-broMo-5-Methylpyridine-1-o×ide
  • 2-bromo-5-methylpyridine N-oxide
  • 19230-58-1