2-Bromo-5-fluoroisonicotinaldehyde
- Product Name
- 2-Bromo-5-fluoroisonicotinaldehyde
- CAS No.
- 1005291-43-9
- Chemical Name
- 2-Bromo-5-fluoroisonicotinaldehyde
- Synonyms
- Benzene,1,2-dichloro-7-methoxy-;2-Bromo-5-fluoro-4-formylpyridine;2-broMo-5-fluoroisonicotinaldehyde;2-Bromo-5-fluoroisonicotinaldehyde98%;2-Bromo-5-fluoroisonicotinaldehyde 98%;2-bromo-5-fluoropyridine-4-carbaldehyde;2-Bromo-5-fluoro-4-pyridine formaldehyde;2-Bromo-5-fluoropyridine-4-carboxaldehyde;2-Bromo-5-fluoro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2-bromo-5-fluoro-
- CBNumber
- CB61177127
- Molecular Formula
- C6H3BrFNO
- Formula Weight
- 204
- MOL File
- 1005291-43-9.mol
2-Bromo-5-fluoroisonicotinaldehyde Property
- Boiling point:
- 251.7±35.0 °C(Predicted)
- Density
- 1.778±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -3.62±0.18(Predicted)
- form
- solid
- color
- Faint yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B700613
- Product name
- 2-Bromo-5-fluoroisonicotinaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B700613
- Product name
- 2-Bromo-5-fluoroisonicotinaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 215013
- Product name
- 2-Bromo-5-fluoroisonicotinaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 4H15-B-X3
- Product name
- 2-Bromo-5-fluoroisonicotinaldehyde
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B10163
- Product name
- 2-Bromo-5-fluoro-4-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
2-Bromo-5-fluoroisonicotinaldehyde Chemical Properties,Usage,Production
Synthesis
41404-58-4
68-12-2
1005291-43-9
Slowly add n-butyllithium (2.4 M in THF, 55.5 mL) dropwise to a solution of diisopropylamine (24.64 g) in THF (100 mL) at -70 °C. During the dropwise addition, ensure that the temperature of the reaction system does not exceed -70 °C. After the dropwise addition was completed, the temperature was slowly warmed to -10 °C and subsequently cooled to -70 °C again. At -70 °C, a solution of 2-bromo-5-fluoropyridine (19.48 g) in THF (100 mL) was added to the reaction system, kept at -70 °C and stirred for 2 hours. Subsequently, N,N-dimethylformamide (16.3 g) was added slowly and dropwise, maintaining the temperature at -70 °C and continuing to stir for 2 hours. 4M hydrochloric acid-dioxane solution (111 mL) was added slowly, ensuring that the temperature of the reaction system did not exceed -70 °C during the dropwise addition. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed sequentially with water and saturated brine solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography to afford the target product 2-bromo-5-fluoro-4-pyridinecarboxaldehyde (20.28 g).
References
[1] Patent: WO2009/10801, 2009, A1. Location in patent: Page/Page column 69-70
[2] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 0732; 0733; 0734
[3] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0185-0188
[4] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0700; 0702-0704
2-Bromo-5-fluoroisonicotinaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluoroisonicotinaldehyde manufacturers
- Product
- 2-Bromo-5-fluoro-4-formylpyridine 1005291-43-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07