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2-Bromo-5-fluoroisonicotinaldehyde

Product Name
2-Bromo-5-fluoroisonicotinaldehyde
CAS No.
1005291-43-9
Chemical Name
2-Bromo-5-fluoroisonicotinaldehyde
Synonyms
Benzene,1,2-dichloro-7-methoxy-;2-Bromo-5-fluoro-4-formylpyridine;2-broMo-5-fluoroisonicotinaldehyde;2-Bromo-5-fluoroisonicotinaldehyde98%;2-Bromo-5-fluoroisonicotinaldehyde 98%;2-bromo-5-fluoropyridine-4-carbaldehyde;2-Bromo-5-fluoro-4-pyridine formaldehyde;2-Bromo-5-fluoropyridine-4-carboxaldehyde;2-Bromo-5-fluoro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2-bromo-5-fluoro-
CBNumber
CB61177127
Molecular Formula
C6H3BrFNO
Formula Weight
204
MOL File
1005291-43-9.mol
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2-Bromo-5-fluoroisonicotinaldehyde Property

Boiling point:
251.7±35.0 °C(Predicted)
Density 
1.778±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-3.62±0.18(Predicted)
form 
solid
color 
Faint yellow
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B700613
Product name
2-Bromo-5-fluoroisonicotinaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B700613
Product name
2-Bromo-5-fluoroisonicotinaldehyde
Packaging
100mg
Price
$60
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B10163
Product name
2-Bromo-5-fluoro-4-formylpyridine
Purity
98%
Packaging
1g
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-B-X3
Product name
2-Bromo-5-fluoroisonicotinaldehyde
Packaging
250mg
Price
$60
Updated
2021/12/16
Oakwood
Product number
215013
Product name
2-Bromo-5-fluoroisonicotinaldehyde
Purity
97%
Packaging
1g
Price
$64
Updated
2021/12/16
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2-Bromo-5-fluoroisonicotinaldehyde Chemical Properties,Usage,Production

Synthesis

41404-58-4

68-12-2

1005291-43-9

Slowly add n-butyllithium (2.4 M in THF, 55.5 mL) dropwise to a solution of diisopropylamine (24.64 g) in THF (100 mL) at -70 °C. During the dropwise addition, ensure that the temperature of the reaction system does not exceed -70 °C. After the dropwise addition was completed, the temperature was slowly warmed to -10 °C and subsequently cooled to -70 °C again. At -70 °C, a solution of 2-bromo-5-fluoropyridine (19.48 g) in THF (100 mL) was added to the reaction system, kept at -70 °C and stirred for 2 hours. Subsequently, N,N-dimethylformamide (16.3 g) was added slowly and dropwise, maintaining the temperature at -70 °C and continuing to stir for 2 hours. 4M hydrochloric acid-dioxane solution (111 mL) was added slowly, ensuring that the temperature of the reaction system did not exceed -70 °C during the dropwise addition. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed sequentially with water and saturated brine solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography to afford the target product 2-bromo-5-fluoro-4-pyridinecarboxaldehyde (20.28 g).

References

[1] Patent: WO2009/10801, 2009, A1. Location in patent: Page/Page column 69-70
[2] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 0732; 0733; 0734
[3] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0185-0188
[4] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0700; 0702-0704

2-Bromo-5-fluoroisonicotinaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluoroisonicotinaldehyde Suppliers

China 92 India 3 Switzerland 1 United Kingdom 2 United States 7 Global 105
Achemica
Tel
--
Fax
--
Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
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View Lastest Price from 2-Bromo-5-fluoroisonicotinaldehyde manufacturers

Career Henan Chemical Co
Product
2-Bromo-5-fluoro-4-formylpyridine 1005291-43-9
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-07

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