Methyl 3-fluoro-4-forMylbenzoate
- Product Name
- Methyl 3-fluoro-4-forMylbenzoate
- CAS No.
- 74733-25-8
- Chemical Name
- Methyl 3-fluoro-4-forMylbenzoate
- Synonyms
- Methyl 3-fluoro-4-forMylbenzoate;4-Methyl 3-fluoro-4-formylbenzoate;3-Fluoro-4-formylbenzoic acid methyl ester;Benzoic acid, 3-fluoro-4-formyl-, methyl ester
- CBNumber
- CB52616680
- Molecular Formula
- C9H7FO3
- Formula Weight
- 182.15
- MOL File
- 74733-25-8.mol
Methyl 3-fluoro-4-forMylbenzoate Property
- Boiling point:
- 290.9±30.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Cream
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 119597
- Product name
- Methyl 3-fluoro-4-formylbenzoate
- Packaging
- 1.00g
- Price
- $270
- Updated
- 2026/05/18
- Product number
- 119597
- Product name
- Methyl 3-fluoro-4-formylbenzoate
- Packaging
- 5.00g
- Price
- $810
- Updated
- 2026/05/18
- Product number
- M51286
- Product name
- Methyl 3-fluoro-4-formylbenzoate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $23
- Updated
- 2026/05/06
- Product number
- M51286
- Product name
- Methyl 3-fluoro-4-formylbenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $29
- Updated
- 2026/05/06
- Product number
- M51286
- Product name
- Methyl 3-fluoro-4-formylbenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $80
- Updated
- 2026/05/06
Methyl 3-fluoro-4-forMylbenzoate Chemical Properties,Usage,Production
Synthesis
193290-80-1
74-88-4
74733-25-8
General procedure for the synthesis of methyl 3-fluoro-4-formylbenzoate (compound 14D) from 3-fluoro-4-formylbenzoic acid (compound 14C, 0.25 g, 1.49 mmol) and iodomethane: Compound 14C was dissolved in DMF (4.5 mL), and sodium hydride (60% oil dispersion, 0.069 g, 1.73 mmol) was added. The reaction mixture was stirred under nitrogen protection for 30 min, followed by the addition of iodomethane (0.11 mL, 1.74 mmol). The reaction was stirred continuously at room temperature for about 15 hours. Upon completion of the reaction, the mixture was poured into 1N HCl solution and extracted several times with EtOAc. The organic phases were combined, washed with saturated brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give compound 14D as a wet residue, which solidified to a white solid after standing (0.23 g, 85% yield).
References
[1] Patent: WO2008/130584, 2008, A1. Location in patent: Page/Page column 144-145
[2] Patent: WO2013/74641, 2013, A1. Location in patent: Paragraph 00382
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 17, p. 4804 - 4807
[4] Patent: WO2004/89916, 2004, A1. Location in patent: Page 22-23
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 19, p. 5950 - 5966
Methyl 3-fluoro-4-forMylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-fluoro-4-forMylbenzoate manufacturers
- Product
- Methyl 3-fluoro-4-forMylbenzoate 74733-25-8
- Price
- US $138.00-1333.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 1kg
- Release date
- 2023-12-18