(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

Uses

Product Name: (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat
CAS No.: 1033805-28-5
Chemical Name: (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat
Synonyms: LX-1033;EOS-61310;LP 778902;Telotristat;Telotrisalt;2H7]-Telotristat;Telotristat, LP778902;LP-778902/ Telotristat;Telotristat, 10 mM in DMSO;LP778902;LP 778902;LP-778902
CBNumber: CB52618578
Molecular Formula: C25H22ClF3N6O3
Formula Weight: 546.93
MOL File: 1033805-28-5.mol

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(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat Property

Boiling point:: 731.1±70.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≥27.35 mg/mL in DMSO with ultrasonic; insoluble in H2O; insoluble in EtOH
form: Powder
pka: 2.04±0.10(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29424
Product name: Telotristat
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 29424
Product name: Telotristat
Packaging: 10mg
Price: $129
Updated: 2024/03/01

TRC

Product number: T017090
Product name: Telotristat
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

TRC

Product number: T017090
Product name: Telotristat
Packaging: 25mg
Price: $1320
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611607
Product name: Telotristat
Packaging: 250mg
Price: $1356.6
Updated: 2021/12/16

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(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat Chemical Properties,Usage,Production

Uses

Telotristat acts as a tryptophan hydroxylase (TPH) inhibitor.

Uses

Telotristat acts as a tryptophan hydroxylase (TPH) inhibitor.

Definition

ChEBI: Telotristat is a phenylalanine derivative.

Biological Activity

telotristat is the active metabolite of lx1606(telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (tph) inhibitor with potential antiserotonergic activity.

in vivo

Telotristat etiprate is present in very low levels after oral administration. These low levels are due to rapid hydrolysis into the active moiety telotristat. The half-life ranges from approximately 4-12 h. There is no accumulation of telotristat with multiple dose administration over 2 weeks. Exposure to telotristat is approximately dose proportional^[1].

(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat Suppliers

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View Lastest Price from (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Telotristat 1033805-28-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Telotristat 1033805-28-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat 1033805-28-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-23

1033805-28-5, (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, TelotristatRelated Search:

LX-1606 Hippurate

(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

Telotristat

(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid

LP 778902

LP-778902/ Telotristat

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoicacid

Telotristat, LP778902

Telotrisalt

EOS-61310

4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine

LX-1033

LP778902;LP 778902;LP-778902

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-

2H7]-Telotristat

inhibit,Telotristat,LP778902,Inhibitor,Tryptophan Hydroxylase,LP 778902,LP-778902

Telotristat, 10 mM in DMSO

1033805-28-5

C25H22ClF3N6O3