LX-1606 Hippurate

Product Name: LX-1606 Hippurate
CAS No.: 1033805-22-9
Chemical Name: LX-1606 Hippurate
Synonyms: LX 1606;LX-1032;Telotrista;LX-1606 Hippurate;Telotristat ethyl;Ethyl Telotristat;LX 1606 (Telotristat);2H7]-Telotristat ethyl;TELOTRISTAT ETHYL (LX1606);LX1606 (Telotristat ethyl)
CBNumber: CB92516023
Molecular Formula: C27H26ClF3N6O3
Formula Weight: 574.98
MOL File: 1033805-22-9.mol

More

Less

LX-1606 Hippurate Property

Melting point:: 80-82°C
Boiling point:: 704.7±70.0 °C(Predicted)
Density: 1.42
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.72±0.33(Predicted)
form: Solid
color: White to Off-White
InChIKey: MDSQOJYHHZBZKA-GBXCKJPGSA-N
SMILES: C(OCC)(=O)[C@H](CC1=CC=C(C2C=C(O[C@H](C3=CC=C(Cl)C=C3N3C=CC(C)=N3)C(F)(F)F)N=C(N)N=2)C=C1)N

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: T017098
Product name: TelotristatEthyl
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-2311
Product name: Telotristatethyl
Purity: 99.68%
Packaging: 5mg
Price: $156
Updated: 2021/12/16

Activate Scientific

Product number: AS59453
Product name: Telotristat
Purity: 95+%
Packaging: 100mg
Price: $169
Updated: 2021/12/16

ChemScene

Product number: CS-2311
Product name: Telotristatethyl
Purity: 99.68%
Packaging: 10mg
Price: $288
Updated: 2021/12/16

Activate Scientific

Product number: AS59453
Product name: Telotristat
Purity: 95+%
Packaging: 250mg
Price: $352
Updated: 2021/12/16

More

Less

LX-1606 Hippurate Chemical Properties,Usage,Production

Uses

Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.

in vivo

Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation^[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis^[2].

LX-1606 Hippurate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LX-1606 Hippurate Suppliers

China 98 France 1 India 1 United States 11 Global 111

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 4115
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

PSN Pharmaceutical Technology Co., Ltd.

Tel: 86-25-57062118
Fax: 86-25-57065896
Email: sales@jspsn.com
Country: China
ProdList: 496
Advantage: 57

Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993961550 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 795
Advantage: 61

Anhui nuoquan pharmaceutical co. LTD

Tel: 15705561919
Fax: 0556-5032869
Email: chunli.yi@nuozhanchem.com
Country: China
ProdList: 90
Advantage: 55

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
Advantage: 60

shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
Email: sales@cooperpharm.com
Country: China
ProdList: 1210
Advantage: 56

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

1033805-22-9, LX-1606 HippurateRelated Search:

(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

LX-1606 Hippurate

LX 1606

LX 1606 (Telotristat)

ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate

Telotristat Impurity 1（Ethyl Telotristat）

TELOTRISTAT ETHYL;LX1606;LX-1606

L-Phenylalanine, 4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyriMidinyl]-, ethyl ester, LX-1606

Telotristat ethyl

(S)-ethyl 2-aMino-3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)propanoate 2-benzaMidoacetate

LX1606(1033805-22-9) HIPPURATE

(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester

LX-1032

(S)-2-amino-3-[4-(2-amino-6-{R-1-[4-chloro-2-(3-methyl-pyrazol-1-yl)-phenyl]-2,2,2-trifluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid ethyl ester

Telotrista

1033805-22-9 LX-1606 Hippurate

ethyl (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

(S)-Ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-t

(S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

Ethyl Telotristat

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

TELOTRISTAT ETHYL (LX1606)

LX1606 (Telotristat ethyl)

2H7]-Telotristat ethyl

Telotristat ethyl, 10 mM in DMSO

Telotristat ethyl (LX 1606 ethyl )

13C3,2H4]-Telotristat ethyl

1033805-22-9

C27H26ClF3N6O3