LX-1606 Hippurate

Product Name: LX-1606 Hippurate
CAS No.: 1033805-22-9
Chemical Name: LX-1606 Hippurate
Synonyms: LX 1606;LX-1032;Telotrista;LX-1606 Hippurate;Telotristat ethyl;Ethyl Telotristat;LX 1606 (Telotristat);2H7]-Telotristat ethyl;TELOTRISTAT ETHYL (LX1606);LX1606 (Telotristat ethyl)
CBNumber: CB92516023
Molecular Formula: C27H26ClF3N6O3
Formula Weight: 574.98
MOL File: 1033805-22-9.mol

More

Less

LX-1606 Hippurate Property

Melting point:: 80-82°C
Boiling point:: 704.7±70.0 °C(Predicted)
Density: 1.42
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.72±0.33(Predicted)
form: Solid
color: White to Off-White
InChIKey: MDSQOJYHHZBZKA-GBXCKJPGSA-N
SMILES: C(OCC)(=O)[C@H](CC1=CC=C(C2C=C(O[C@H](C3=CC=C(Cl)C=C3N3C=CC(C)=N3)C(F)(F)F)N=C(N)N=2)C=C1)N

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: T017098
Product name: TelotristatEthyl
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-2311
Product name: Telotristatethyl
Purity: 99.68%
Packaging: 5mg
Price: $156
Updated: 2021/12/16

Activate Scientific

Product number: AS59453
Product name: Telotristat
Purity: 95+%
Packaging: 100mg
Price: $169
Updated: 2021/12/16

ChemScene

Product number: CS-2311
Product name: Telotristatethyl
Purity: 99.68%
Packaging: 10mg
Price: $288
Updated: 2021/12/16

Activate Scientific

Product number: AS59453
Product name: Telotristat
Purity: 95+%
Packaging: 250mg
Price: $352
Updated: 2021/12/16

More

Less

LX-1606 Hippurate Chemical Properties,Usage,Production

Uses

Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.

in vivo

Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation^[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis^[2].

LX-1606 Hippurate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LX-1606 Hippurate Suppliers

China 97 France 1 India 1 United States 11 Global 110

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2935
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

PSN Pharmaceutical Technology Co., Ltd.

Tel: 86-25-57062118
Fax: 86-25-57065896
Email: sales@jspsn.com
Country: China
ProdList: 496
Advantage: 57

Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 806
Advantage: 61

Anhui nuoquan pharmaceutical co. LTD

Tel: 15705561919
Fax: 0556-5032869
Email: chunli.yi@nuozhanchem.com
Country: China
ProdList: 101
Advantage: 55

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
Advantage: 60

shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
Email: sales@cooperpharm.com
Country: China
ProdList: 1210
Advantage: 56

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

1033805-22-9, LX-1606 HippurateRelated Search:

(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

LX-1606 Hippurate

LX 1606

LX 1606 (Telotristat)

ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate

Telotristat Impurity 1（Ethyl Telotristat）

TELOTRISTAT ETHYL;LX1606;LX-1606

L-Phenylalanine, 4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyriMidinyl]-, ethyl ester, LX-1606

Telotristat ethyl

(S)-ethyl 2-aMino-3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)propanoate 2-benzaMidoacetate

LX1606(1033805-22-9) HIPPURATE

(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester

LX-1032

(S)-2-amino-3-[4-(2-amino-6-{R-1-[4-chloro-2-(3-methyl-pyrazol-1-yl)-phenyl]-2,2,2-trifluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid ethyl ester

Telotrista

1033805-22-9 LX-1606 Hippurate

ethyl (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

(S)-Ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-t

(S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

Ethyl Telotristat

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

TELOTRISTAT ETHYL (LX1606)

LX1606 (Telotristat ethyl)

2H7]-Telotristat ethyl

Telotristat ethyl, 10 mM in DMSO

Telotristat ethyl (LX 1606 ethyl )

1033805-22-9

C27H26ClF3N6O3