PCI 34051

ChemicalBook > CAS DataBase List > PCI 34051

Product Name: PCI 34051
CAS No.: 950762-95-5
Chemical Name: PCI 34051
Synonyms: PCI-34051;PCI 34051;PCI-34051;PCI 34051;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
CBNumber: CB52622953
Molecular Formula: C17H16N2O3
Formula Weight: 296.32
MOL File: 950762-95-5.mol

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PCI 34051 Property

Density: 1.25
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
form: Powder
pka: 9.16±0.30(Predicted)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 50mg
Price: $602
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 100mg
Price: $829
Updated: 2024/03/01

Tocris

Product number: 4643
Product name: PCI34051
Purity: ≥98%(HPLC)
Packaging: 50
Price: $471
Updated: 2021/12/16

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PCI 34051 Chemical Properties,Usage,Production

Uses

PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Definition

ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.

Biological Activity

pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.

storage

-20°C

PCI 34051 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PCI 34051 manufacturers

Career Henan Chemical Co

Product: N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

Career Henan Chemical Co

Product: N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

950762-95-5, PCI 34051Related Search:

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N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide

PCI 34051

PCI-34051

1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide

1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-

N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

PCI-34051;PCI 34051

N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide

950762-95-5

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Aromatics

Heterocycles

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