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PCI 34051

Product Name
PCI 34051
CAS No.
950762-95-5
Chemical Name
PCI 34051
Synonyms
PCI-34051;PCI 34051;PCI-34051;PCI 34051;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
CBNumber
CB52622953
Molecular Formula
C17H16N2O3
Formula Weight
296.32
MOL File
950762-95-5.mol
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PCI 34051 Property

Density 
1.25
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
form 
Powder
pka
9.16±0.30(Predicted)
color 
White to gray
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10444
Product name
PCI 34051
Purity
≥95%
Packaging
5mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
10444
Product name
PCI 34051
Purity
≥95%
Packaging
10mg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
10444
Product name
PCI 34051
Purity
≥95%
Packaging
50mg
Price
$602
Updated
2024/03/01
Cayman Chemical
Product number
10444
Product name
PCI 34051
Purity
≥95%
Packaging
100mg
Price
$829
Updated
2024/03/01
Tocris
Product number
4643
Product name
PCI34051
Purity
≥98%(HPLC)
Packaging
50
Price
$471
Updated
2021/12/16
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PCI 34051 Chemical Properties,Usage,Production

Uses

PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Definition

ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.

Biological Activity

pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.

storage

-20°C

PCI 34051 Preparation Products And Raw materials

Raw materials

Preparation Products

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PCI 34051 Suppliers

A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from PCI 34051 manufacturers

Career Henan Chemical Co
Product
N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

950762-95-5, PCI 34051Related Search:


  • N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide
  • PCI 34051
  • PCI-34051
  • 1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide
  • 1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
  • N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
  • PCI-34051;PCI 34051
  • N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
  • 950762-95-5
  • Apoptosis
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor