2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)

Product Name: 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)
CAS No.: 245075-84-7
Chemical Name: 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)
Synonyms: LR-90;AGE Inhibitor, LR-90;LR-90, 10 mM in DMSO;inhibit,Inhibitor,LR-90,LR90,LR 90;2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phenyleneoxy]}bis(2-methylpropanoic acid);2,2-[Methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methylpropanoic acid];Propanoic acid, 2,2'-[methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methyl-;2,2'-((((((methylenebis(2-chloro-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(2-methylpropanoic acid);2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid);2-(4-{[(4-{[4-({[4-(1-carboxy-1-methylethoxy)phenyl]carbamoyl}amino)-3-chlorophenyl]methyl}-2-chlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid
CBNumber: CB52623839
Molecular Formula: C35H34Cl2N4O8
Formula Weight: 709.57
MOL File: 245075-84-7.mol

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2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) Property

Boiling point:: 726.0±60.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (140.93 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 3.01±0.10(Predicted)
color: White to off-white

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573260
Product name: LR-90
Purity: >98%
Packaging: 100mg
Price: $1208.7
Updated: 2021/12/16

ChemScene

Product number: CS-M0920
Product name: 2,2'-(4,4'-(4,4'-methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-methylpropanoicacid)
Purity: 99.49%
Packaging: 50mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-M0920
Product name: 2,2'-(4,4'-(4,4'-methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-methylpropanoicacid)
Purity: 99.49%
Packaging: 100mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-M0920
Product name: 2,2'-(4,4'-(4,4'-methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-methylpropanoicacid)
Purity: 99.49%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-M0920
Product name: 2,2'-(4,4'-(4,4'-methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-methylpropanoicacid)
Purity: 99.49%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

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2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) Chemical Properties,Usage,Production

Uses

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes[1]. LR-90 is also used in the research of diabetic animal model[2].

Biological Activity

Cell permeable: yes', 'Primary Target
=IF(SGM_MetricTransfer!C11=,,SGM_MetricTransfer!C11)

in vivo

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats^[2].
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation^[2].

Animal Model:	Male ZDF rats (13 to 40 weeks)^[2]
Dosage:	50 mg/L
Administration:	P.O. for 27 weeks
Result:	Significantly reduced plasma triacylglycerol and cholesterol by ～55% and ～30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.

References

[1] Figarola JL, et al. Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes. Diabetes. 2007 Mar;56(3):647-55. DOI:10.2337/db06-0936
[2] Figarola JL, et al. LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia. 2008 May;51(5):882-91. DOI:10.1007/s00125-008-0935-x

2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) Suppliers

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245075-84-7, 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)Related Search:

2-Methylpropanedioic acid Thionyl chloride Dichloromethane

2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)

2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phenyleneoxy]}bis(2-methylpropanoic acid)

2,2-[Methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methylpropanoic acid]

2,2'-((((((methylenebis(2-chloro-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(2-methylpropanoic acid)

LR-90

Propanoic acid, 2,2'-[methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methyl-

inhibit,Inhibitor,LR-90,LR90,LR 90

2-(4-{[(4-{[4-({[4-(1-carboxy-1-methylethoxy)phenyl]carbamoyl}amino)-3-chlorophenyl]methyl}-2-chlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid

LR-90, 10 mM in DMSO

AGE Inhibitor, LR-90

245075-84-7

C35H34Cl2N4O8