INCB3344

Product Name: INCB3344
CAS No.: 1262238-11-8
Chemical Name: INCB3344
Synonyms: INCB 3344;INCB-3344;CC chemokine receptor,INCB3344,CCR,Inhibitor,inhibit,INCB-3344,INCB 3344;rel-N-[2-[[(3R,4R)-1-[trans-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-
CBNumber: CB52624184
Molecular Formula: C29H34F3N3O6
Formula Weight: 577.59
MOL File: 1262238-11-8.mol

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INCB3344 Property

Boiling point:: 736.3±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥25.9 mg/mL in DMSO; insoluble in H2O; ≥89.8 mg/mL in EtOH
form: solid
pka: 12.94±0.46(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28433
Product name: INCB 3344
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 28433
Product name: INCB 3344
Packaging: 10mg
Price: $638
Updated: 2024/03/01

Cayman Chemical

Product number: 28433
Product name: INCB 3344
Packaging: 5mg
Price: $343
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0000598
Product name: INCB-3344
Purity: 95.00%
Packaging: 5MG
Price: $496.23
Updated: 2021/12/16

ChemScene

Product number: CS-0347
Product name: INCB3344
Purity: 99.73%
Packaging: 50mg
Price: $810
Updated: 2021/12/16

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INCB3344 Chemical Properties,Usage,Production

Description

INCB 3344 is an antagonist of chemokine (C-C motif) receptor 2 (CCR2; IC₅₀ = 10 nM in WEHI-274 murine monocytes). It is selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC₅₀s values greater than 1 μM. INCB 3344 inhibits chemotaxis of WEHI-274 cells induced by chemokine (C-C motif) ligand 2 (CCL2; IC₅₀ = 10 nM) and CCL2-induced phosphorylation of ERK in WEHI-274 cells. It inhibits monocyte influx in a mouse model of peritonitis induced by thioglycolate when administered at doses of 60 and 100 mg/kg. INCB 3344 (30, 50, and 100 mg/kg twice per day) decreases the expression of CCR2 mRNA in the ear and reduces ear swelling in a mouse model of delayed-type hypersensitivity reaction. It prevents increases in or reduces macrophage levels in the spinal cord when administered at a dose of 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of experimental autoimmune encephalomyelitis (EAE). It also reduces disease incidence and severity in the same model and reduces disease severity in a rat model of adjuvant-induced arthritis. INCB 3344 reduces macrophage infiltration to the kidney and improves renal function in a mouse model of polycystic kidney disease.

References

[1]. brodmerkel c m, huber r, covington m, et al. discovery and pharmacological characterization of a novel rodent-active ccr2 antagonist, incb3344[j]. the journal of immunology, 2005, 175(8): 5370-5378.

INCB3344 Preparation Products And Raw materials

Raw materials

Preparation Products

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INCB3344 Suppliers

China 36 United States 8 Global 44

Shanghai Boyle Chemical Co., Ltd.

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MedChemexpress LLC

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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DKMbiochem.Co. Ltd

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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SPIRO PHARMA

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Codow Chemical Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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1262238-11-8, INCB3344Related Search:

INCB 3344;INCB-3344

rel-N-[2-[[(3R,4R)-1-[trans-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-

CC chemokine receptor,INCB3344,CCR,Inhibitor,inhibit,INCB-3344,INCB 3344

1262238-11-8

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