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Regorafenib (Hydrochloride)

Product Name
Regorafenib (Hydrochloride)
CAS No.
835621-07-3
Chemical Name
Regorafenib (Hydrochloride)
Synonyms
Regofini;Regorafenib HC;Regafenib HCL;Regorafenib HCl;Regafenib hydrochloride;BAY73-4506 hydrochloride;egorafenib (Hydrochloride);5-Diiodotyrosine Dihydrate;Regorafenib (Hydrochloride);Regorafenib HCl (BAY-73-4506)
CBNumber
CB52624290
Molecular Formula
C21H16Cl2F4N4O3
Formula Weight
519.2763528
MOL File
835621-07-3.mol
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Regorafenib (Hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
≥ 25.95 mg/mL in DMSO, ≥ 8.75 mg/mL in EtOH with ultrasonic and warming
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0725
Product name
Regorafenib(Hydrochloride)
Purity
99.58%
Packaging
50mg
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
A3750
Product name
Regorafenibhydrochloride
Packaging
10mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0725
Product name
Regorafenib(Hydrochloride)
Purity
99.58%
Packaging
100mg
Price
$80
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001550
Product name
REGORAFENIB HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$154
Updated
2021/12/16
AK Scientific
Product number
4001AH
Product name
Regorafenibhydrochloride
Packaging
5mg
Price
$186
Updated
2021/12/16
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Regorafenib (Hydrochloride) Chemical Properties,Usage,Production

Uses

BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

in vitro

Regorafenib potently inhibits VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with an IC50 of 3 nM. In HAoSMCs, regorafenib inhibits PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of 3 nMf. Regorafenib causes a concentration-dependent decrease in Hep3B cell growth, having an IC50 of 5 μM. Regorafenib subsequently increases the levels of phospho-c-Jun, a JNK target, but not total c-Jun in Hep3B cells.

in vivo

Regorafenib effectively inhibits growth of the Colo-205 xenografts in the dose range of 10-100 mg/kg reaching a TGI of 75% at day 14 at the 10 mg/kg dose. In the MDA-MB-231 model, regorafenib is highly efficacious at a dose as low as 3 mg/kg, resulting in a significant TGI of 81%, which increases to 93% at doses of 10 and 30 mg/kg, where tumor stasis is reached.

References

[1] Phan, Chiuyen et al. “Isomorphous Crystals Formed by the Similar Supramolecular Motifs in Sorafenib Hydrochloride and Regorafenib Hydrochloride Salts.” 2019. 0.

Regorafenib (Hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Regorafenib (Hydrochloride) Suppliers

China 121 India 1 United States 8 Global 130
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View Lastest Price from Regorafenib (Hydrochloride) manufacturers

Hebei Duling International Trade Co. LTD
Product
Regorafenib (Hydrochloride) 835621-07-3
Price
US $100.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20 tons
Release date
2023-03-24
Hebei Yanxi Chemical Co., Ltd.
Product
Regorafenib (Hydrochloride) 835621-07-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09
Henan Bao Enluo International TradeCo.，LTD
Product
Regorafenib (Hydrochloride) 835621-07-3
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-07-25

835621-07-3, Regorafenib (Hydrochloride)Related Search:

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide (S,S')-3-METHYL-1-(2-PIPERIDINOPHENYL)BUTYLAMINE, N-ACETYL-GLUTAMATE SALT 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Regorafenib Bortezomib Abiraterone

  • BAY73-4506 hydrochloride
  • 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride
  • Regafenib HCL
  • Regafenib hydrochloride
  • 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, monohydrochloride
  • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride (1:1)
  • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydr
  • Regorafenib (Hydrochloride)
  • Regorafenib HCl
  • 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride
  • Regorafenib HC
  • Powder Regorafenib Hydrochloride CAS
  • Regorafenib Hydrochloride/BAY73-4506 hydrochloride
  • Regorafenib HCl (BAY-73-4506)
  • egorafenib (Hydrochloride)
  • 5-Diiodotyrosine Dihydrate
  • Regofini
  • 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)
  • 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-Pyridinecarboxamide hydrochloride (1:1)
  • 4-4-4-Chloro-3-(trifluoromethyl)phenylaminocarbonylamino-3-fluorophenoxy-N-methylpyridin-2-carboxamide HCl
  • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrochloride
  • 835621-07-3
  • C21H15ClF4N4O3ClH
  • C21H15ClF4N4O3HCl
  • C21H16Cl2F4N4O3