ChemicalBook > CAS DataBase List > VTP-27999 (Hydrochloride)
VTP-27999 (Hydrochloride)
- Product Name
- VTP-27999 (Hydrochloride)
- CAS No.
- 1264191-73-2
- Chemical Name
- VTP-27999 (Hydrochloride)
- Synonyms
- VTP-27999 HCl;VTP-27999 (Hydrochloride);VTP27999; VTP 27999;VTP27999 HYDROCHLORIDE; VTP 27999 HYDROCHLORIDE;methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate hydrochloride;N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamic acid methyl ester hydrochloride (1:1);Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1)
- CBNumber
- CB52624346
- Molecular Formula
- C26H42Cl2N4O5
- Formula Weight
- 561.55
- MOL File
- 1264191-73-2.mol
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VTP-27999 (Hydrochloride) Property
- form
- Powder
- color
- White to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0835
- Product name
- VTP-27999Hydrochloride
- Purity
- 98.10%
- Packaging
- 5mg
- Price
- $456
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0835
- Product name
- VTP-27999Hydrochloride
- Purity
- 98.10%
- Packaging
- 10mg
- Price
- $792
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb611810
- Product name
- VTP-27999 hydrochloride
- Packaging
- 10mg
- Price
- $805.8
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0835
- Product name
- VTP-27999Hydrochloride
- Purity
- 98.10%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb611810
- Product name
- VTP-27999 hydrochloride
- Packaging
- 50mg
- Price
- $1654.1
- Updated
- 2021/12/16
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VTP-27999 (Hydrochloride) Chemical Properties,Usage,Production
Description
VTP-27999 Hydrochloride is a potent inhibitor of renin with IC50 value of 0.3 nM for human renin.
Uses
VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin
target
human renin
References
[1] Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751
[2] New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. DOI:10.1161/HYPERTENSIONAHA.111.00967
[3] Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25. DOI:10.1021/ci200605k
VTP-27999 (Hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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VTP-27999 (Hydrochloride) Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
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- +1-800-259-7612
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- info@musechem.com
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- United States
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- Tel
- +1-781-999-5354;
- support@targetmol.com
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- United States
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- 16314854226
- info@bocsci.com
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- United States
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- info@creative-enzymes.com
- Country
- United States
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