ChemicalBook > CAS DataBase List > A-385358

A-385358

Product Name
A-385358
CAS No.
406228-55-5
Chemical Name
A-385358
Synonyms
A-385358;Paclitaxel Impurity 60;A-385358, 10 mM in DMSO;Bcl-2 Family,A 385358,Inhibitor,A-385358,A385358,inhibit;(S)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;(R)-N-((4-((4-(Dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;Benzamide, N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-
CBNumber
CB52624922
Molecular Formula
C32H41N5O5S2
Formula Weight
639.83
MOL File
406228-55-5.mol
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A-385358 Property

Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (195.36 mM)
form 
Solid
pka
3.71±0.10(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A101035
Product name
A-385358
Packaging
1mg
Price
$285
Updated
2021/12/16
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A-385358 Chemical Properties,Usage,Production

Uses

A-385358, is a selective inhibitor of Bcl-XL with Kis, in vitro. In vivo, A-385358, in combination with the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy.

in vivo

The combination of A-385358 given at 100 mg/kg/d plus the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy. This combination also yields a >100% increase in time for tumors to reach 900 mm3 (%ILS) compare with vehicle control. Maximal efficacy is observed during the dosing period for A-385358, with slow but steady increase in the tumor growth after termination of treatment. The combination of A-385358 at 75 mg/kg/d plus paclitaxel at 30 mg/kg/d is also well tolerated and inhibits tumor growth rate by nearly 80%. Significant effects on tumor growth relative to paclitaxel monotherapy are observed with doses as low as 50 mg/kg/d[1].

IC 50

Bcl-xL: 0.8 nM (Ki); Bcl-2: 67 nM (Ki)

A-385358 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-385358 Suppliers

China 32 United States 3 Global 35
Nanjing Chemlin Chemical Co., Ltd
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Bide Pharmatech Ltd.
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406228-55-5, A-385358Related Search:

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  • A-385358
  • (S)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide
  • Benzamide, N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-
  • Paclitaxel Impurity 60
  • Bcl-2 Family,A 385358,Inhibitor,A-385358,A385358,inhibit
  • A-385358, 10 mM in DMSO
  • (R)-N-((4-((4-(Dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide
  • 406228-55-5
  • C32H41N5O5S2