A-385358

Product Name: A-385358
CAS No.: 406228-55-5
Chemical Name: A-385358
Synonyms: A-385358;Paclitaxel Impurity 60;A-385358, 10 mM in DMSO;Bcl-2 Family,A 385358,Inhibitor,A-385358,A385358,inhibit;(S)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;(R)-N-((4-((4-(Dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide;Benzamide, N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-
CBNumber: CB52624922
Molecular Formula: C32H41N5O5S2
Formula Weight: 639.83
MOL File: 406228-55-5.mol

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A-385358 Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (195.36 mM)
form: Solid
pka: 3.71±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A101035
Product name: A-385358
Packaging: 1mg
Price: $285
Updated: 2021/12/16

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A-385358 Chemical Properties,Usage,Production

Uses

A-385358, is a selective inhibitor of Bcl-XL with Kis, in vitro. In vivo, A-385358, in combination with the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy.

in vivo

The combination of A-385358 given at 100 mg/kg/d plus the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy. This combination also yields a >100% increase in time for tumors to reach 900 mm³ (%ILS) compare with vehicle control. Maximal efficacy is observed during the dosing period for A-385358, with slow but steady increase in the tumor growth after termination of treatment. The combination of A-385358 at 75 mg/kg/d plus paclitaxel at 30 mg/kg/d is also well tolerated and inhibits tumor growth rate by nearly 80%. Significant effects on tumor growth relative to paclitaxel monotherapy are observed with doses as low as 50 mg/kg/d^[1].

IC 50

Bcl-xL: 0.8 nM (Ki); Bcl-2: 67 nM (Ki)

A-385358 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-385358 Suppliers

China 32 United States 3 Global 35

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 498
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

SPIRO PHARMA

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Email: eric_feng1954@126.com
Country: China
ProdList: 9248
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
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Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
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406228-55-5, A-385358Related Search:

(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 7-Xylosyl-10-deacetyltaxol Paclitaxel Impurity 9 N-Desbenzoyl-N-tert-butoxycarbonyl-N,O-isopropylidene-3a€-p-O-benzyl-6,7-dehydro Paclitaxel 2'-O-(Benzyloxycarbonyl) Taxol (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE Epothilone B 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID (4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(triethylsilyl) Baccatin III Docetaxel-D9 Paclitaxel EP Impurity I 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole DHA-paclitaxel

A-385358

(S)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide

Benzamide, N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-

Paclitaxel Impurity 60

Bcl-2 Family,A 385358,Inhibitor,A-385358,A385358,inhibit

A-385358, 10 mM in DMSO

(R)-N-((4-((4-(Dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(4,4-dimethylpiperidin-1-yl)benzamide

406228-55-5

C32H41N5O5S2