AM-095

ChemicalBook > CAS DataBase List > AM-095

Product Name: AM-095
CAS No.: 1345614-59-6
Chemical Name: AM-095
Synonyms: AM-095;AM095 sodium;AM095 >=98% (HPLC);AM-095;AM095;AM 095;AM095 hydrochloride;AM095 (Sodium Salt);LPL Receptor,AM095,inhibit,Lysophospholipid Receptor,Inhibitor,AM-095,AM 095;sodium,2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate;(2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid) sodium salt;4'-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid sodium salt (1:1)
CBNumber: CB52627312
Molecular Formula: C27H25N2NaO5
Formula Weight: 480.5
MOL File: 1345614-59-6.mol

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AM-095 Property

storage temp.: room temp
solubility: ≥23.9 mg/mL in DMSO; insoluble in H2O; ≥16.77 mg/mL in EtOH with ultrasonic
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3166
Product name: AM095
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ApexBio Technology

Product number: A3166
Product name: AM095
Packaging: 10mM(in 1mL DMSO)
Price: $115
Updated: 2021/12/16

ChemScene

Product number: CS-1118
Product name: AM095
Purity: 99.72%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: A3166
Product name: AM095
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-1118
Product name: AM095
Purity: 99.72%
Packaging: 10mg
Price: $168
Updated: 2021/12/16

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AM-095 Chemical Properties,Usage,Production

Biological Activity

am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].

in vitro

am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].

in vivo

am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].

target

LPA1 receptor

References

[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.

AM-095 Preparation Products And Raw materials

Raw materials

Preparation Products

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1345614-59-6, AM-095Related Search:

Octadecyl methacrylate p-Tolualdehyde 2-Methylpropanedioic acid (S)-(+)-Benzyl glycidyl ether Benzyl alcohol 4'-Hydroxyacetophenone

AM-095

4'-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid sodium salt (1:1)

AM095 (Sodium Salt)

AM095 sodium

sodium,2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate

(2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid) sodium salt

AM095 hydrochloride

AM-095;AM095;AM 095

AM095 >=98% (HPLC)

LPL Receptor,AM095,inhibit,Lysophospholipid Receptor,Inhibitor,AM-095,AM 095

1345614-59-6

C27H24N2O5Na

C27H23N2O5Na

C27H23N2NaO5

Inhibitors