Vipadenant

Description References

Product Name: Vipadenant
CAS No.: 442908-10-3
Chemical Name: Vipadenant
Synonyms: V 2006;CS-2294;BIIB 014;CEB 4520;VER 11135;Vipadenant;VER-ADO 49;VER-A 00-11;VER-A 00049;BIIB-014, CEB-4520
CBNumber: CB52627600
Molecular Formula: C16H15N7O
Formula Weight: 321.34
MOL File: 442908-10-3.mol

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Vipadenant Property

Melting point:: 245.3-246.1 °C
Boiling point:: 668.5±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:37.0(Max Conc. mg/mL);115.14(Max Conc. mM)
form: A crystalline solid
pka: 4.27±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20239
Product name: Vipadenant
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 20239
Product name: Vipadenant
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 20239
Product name: Vipadenant
Purity: ≥98%
Packaging: 5mg
Price: $469
Updated: 2024/03/01

TRC

Product number: V670808
Product name: Vipadenant
Packaging: 50mg
Price: $1440
Updated: 2021/12/16

TRC

Product number: V670808
Product name: Vipadenant
Packaging: 5mg
Price: $255
Updated: 2021/12/16

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Vipadenant Chemical Properties,Usage,Production

Description

Vipadenant (also known as BIIB014) is a potent, selective oral adenosine A2A receptor antagonist under development for the treatment of Parkinson’s disease. It has successfully completed phase I clinical studies. It might also be a potential adjunctive therapy reagent for cancer treatment. It was found that it has certain potentials to disrupt an immunosuppressive mechanism of tumour protection, generating improved efficacy for immunotherapies of certain cancers when used in combination with other drugs.

References

http://www.medkoo.com/products/8047
Shook, B. C., and P. F. Jackson. "Adenosine A(2A) Receptor Antagonists and Parkinson's Disease. " Acs Chemical Neuroscience2.10(2011):555-67.
Brooks, D. J., et al. "An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers." Clinical Neuropharmacology 33.2(2010):55.
http://www.vernalis.com/nce-pipeline/oncology/v2006

Uses

Vipadenant is a potent, selective and orally available adenosine A2A receptor antagonist under development for for Parkinson''s disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson''s disease. Vipadenant has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies.

Vipadenant Preparation Products And Raw materials

Raw materials

Preparation Products

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Vipadenant Suppliers

China 63 United States 8 Global 71

Deyang Sino Biotech. Co., LTD

Tel: +86-19182167371 +86-19182167371
Email: service@synlord.com
Country: China
ProdList: 99
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9461
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4456
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1008
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

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View Lastest Price from Vipadenant manufacturers

Career Henan Chemical Co

Product: Vipadenant 442908-10-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

442908-10-3, VipadenantRelated Search:

Vinorelbine tartrate ABT-199

Vipadenant(BIIB 014)

3-[(4-Amino-3-methylphenyl)methyl]-7-(2-furanyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine

CEB 4520

V 2006

VER 11135

VER-A 00049

VER-A 00-11

VER-ADO 49

BIIB 014

Vipadenant

5-BROMO-4-(METHYLSULFANYL)-1H-PYRROLO[2,3-B]PYRIDINE

3-[(4-amino-3-methylphenyl)methyl]-7-(furan-2-yl)triazolo[4,5-d]pyrimidin-5-amine

CS-2294

BIIB-014;BIIB 014;BIIB014

BIIB-014 Vipadenant

3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 3-[(4-amino-3-methylphenyl)methyl]-7-(2-furanyl)-

3-(4-AMINO-3-METHYLBENZYL)-7-(FURAN-2-YL)-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-5- AMINE

CEB 4520,Vipadenant,BIIB 014,BIIB014,CEB4520,inhibit,Adenosine Receptor,Inhibitor,P1 receptor

BIIB-014, CEB-4520

442908-10-3

C16H15N7O

Inhibitors

API