ChemicalBook > CAS DataBase List > GDC-0068

GDC-0068

Product Name
GDC-0068
CAS No.
1001264-89-6
Chemical Name
GDC-0068
Synonyms
Ipatasertib;Cenicriviroc mesylate;RG7440;CS-543;GDC-0068;EOS-62198;patasertib;GDC-0068(RG7440);GDC-0068 USP/EP/BP;Ipatasertib (GDC-0068)
CBNumber
CB52627897
Molecular Formula
C24H32ClN5O2
Formula Weight
458
MOL File
1001264-89-6.mol
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GDC-0068 Property

Melting point:
>106°C (dec.)
Boiling point:
669.4±55.0 °C(Predicted)
Density 
1.254
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Soluble in DMSO.
pka
13.11±0.40(Predicted)
form 
Solid
color 
peachy
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67082
Product name
GDC-0068, 98%
Packaging
5mg
Price
$241
Updated
2023/06/20
Cayman Chemical
Product number
18412
Product name
GDC-0068
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
18412
Product name
GDC-0068
Purity
≥98%
Packaging
5mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
18412
Product name
GDC-0068
Purity
≥98%
Packaging
10mg
Price
$437
Updated
2024/03/01
Cayman Chemical
Product number
18412
Product name
GDC-0068
Purity
≥98%
Packaging
25mg
Price
$957
Updated
2024/03/01
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GDC-0068 Chemical Properties,Usage,Production

Uses

DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.

Uses

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.

Uses

GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.

Definition

ChEBI: (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl]-3-(propan-2-ylamino)-1-propanone is a N-arylpiperazine.

Biological Activity

gdc-0068 (rg7440) is a highly selective small molecule inhibitor of akt with ic50s of 5, 18 and 8 nm for akt1, akt2 and akt3. the pi3k-akt pathway regulates cell growth, survival and tumorigenesis. gdc-0068 binds to and blocks the activation of akt, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. pi3k-akt is pathway frequently activated in tumors, thus tumors with pten or pi3k mutations, which lead to activation of akt are with high sensitivity to gdc-0068. gdc-0068 is now used for the treatment of human cancers.1. discovery and preclinical pharmacology of a selective atp-competitive akt inhibitor (gdc-0068) for the treatment of human tumors. jf blake, r xu, jr bencsik, d xiao… - journal of medicinal 20122. lin j, sampath d, nannini ma, et al: targeting activated akt with gdc-0068, a novel selective akt inhibitor that is efficacious in multiple tumor models. clin canc res 2013, 19:1760–1772.

target

Akt1

GDC-0068 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0068 Suppliers

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View Lastest Price from GDC-0068 manufacturers

Career Henan Chemical Co
Product
GDC-0068 1001264-89-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1001264-89-6, GDC-0068Related Search:


  • GDC-0068
  • GDC-0068(RG7440)
  • RG7440
  • (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
  • Ipatasertib (GDC-0068)
  • GDC0068;GDC 0068;GDC-0068;RG7440;RG-7440;;RG 7440
  • Ipatasertib
  • (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one
  • (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone Ipatasertib (GDC-0068)
  • GDC-0068 (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
  • (2S)-2-(4-Chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl}-3-(isopropylamino)-1-propanone
  • Ipatasertib (GDC-0068,RG 7440)
  • Cenicriviroc mesylate
  • GDC-0068;RG7440; GDC0068; GDC 0068; RG-7440; RG 7440
  • GDC-0068 (Ipatasertib)
  • (S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-
  • EOS-62198
  • GDC-0068, 98%, a highly selective pan-Akt inhibitor
  • CS-543
  • GDC0068;GDC 0068;GDC-0068
  • GDC-0068 (Ipatasertib,RG-7440)
  • 1-Propanone, 2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2S)-
  • GDC-0068 USP/EP/BP
  • patasertib
  • GDC-0068 Ipatasertib RG-7440 GDC0068 RG7440
  • 1001264-89-6
  • 1002364-89-6
  • C24H32ClN5O2
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • Inhibitor
  • PI3K/Akt/mTOR