GDC-0068
- Product Name
- GDC-0068
- CAS No.
- 1001264-89-6
- Chemical Name
- GDC-0068
- Synonyms
- Ipatasertib;Cenicriviroc mesylate;RG7440;CS-543;GDC-0068;EOS-62198;patasertib;GDC-0068(RG7440);GDC-0068 USP/EP/BP;Ipatasertib (GDC-0068)
- CBNumber
- CB52627897
- Molecular Formula
- C24H32ClN5O2
- Formula Weight
- 458
- MOL File
- 1001264-89-6.mol
GDC-0068 Property
- Melting point:
- >106°C (dec.)
- Boiling point:
- 669.4±55.0 °C(Predicted)
- Density
- 1.254
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Soluble in DMSO.
- pka
- 13.11±0.40(Predicted)
- form
- Solid
- color
- peachy
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J67082
- Product name
- GDC-0068, 98%
- Packaging
- 5mg
- Price
- $241
- Updated
- 2023/06/20
- Product number
- 18412
- Product name
- GDC-0068
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 18412
- Product name
- GDC-0068
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 18412
- Product name
- GDC-0068
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 18412
- Product name
- GDC-0068
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $957
- Updated
- 2024/03/01
GDC-0068 Chemical Properties,Usage,Production
Uses
DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.
Uses
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
Uses
GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
Definition
ChEBI: (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl]-3-(propan-2-ylamino)-1-propanone is a N-arylpiperazine.
Biological Activity
gdc-0068 (rg7440) is a highly selective small molecule inhibitor of akt with ic50s of 5, 18 and 8 nm for akt1, akt2 and akt3. the pi3k-akt pathway regulates cell growth, survival and tumorigenesis. gdc-0068 binds to and blocks the activation of akt, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. pi3k-akt is pathway frequently activated in tumors, thus tumors with pten or pi3k mutations, which lead to activation of akt are with high sensitivity to gdc-0068. gdc-0068 is now used for the treatment of human cancers.1. discovery and preclinical pharmacology of a selective atp-competitive akt inhibitor (gdc-0068) for the treatment of human tumors. jf blake, r xu, jr bencsik, d xiao… - journal of medicinal 20122. lin j, sampath d, nannini ma, et al: targeting activated akt with gdc-0068, a novel selective akt inhibitor that is efficacious in multiple tumor models. clin canc res 2013, 19:1760–1772.
target
Akt1
GDC-0068 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GDC-0068 manufacturers
- Product
- GDC-0068 1001264-89-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23