LY 450108
- Product Name
- LY 450108
- CAS No.
- 376594-67-1
- Chemical Name
- LY 450108
- Synonyms
- 100782;LY 450108;LY 450108;LY-450108;LY450108, 10 mM in DMSO;Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-;N-[4-[(1R)-1-Methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-3,5-difluorophenylcarboxamide;Inhibitor,inhibit,AMPA,Parkinson's,LY 450108,depression,iGluR,LY-450108,LY450108,Ionotropic glutamate receptors
- CBNumber
- CB52628061
- Molecular Formula
- C19H22F2N2O3S
- Formula Weight
- 396.45
- MOL File
- 376594-67-1.mol
LY 450108 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 50 mg/mL (126.12 mM); Water: < 0.1 mg/mL (insoluble)
- form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0013995
- Product name
- LY-450108
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $284.55
- Updated
- 2021/12/16
- Product number
- CS-1090
- Product name
- LY450108
- Purity
- 99.51%
- Packaging
- 5mg
- Price
- $286
- Updated
- 2021/12/16
- Product number
- CS-1090
- Product name
- LY450108
- Purity
- 99.51%
- Packaging
- 10mg
- Price
- $436
- Updated
- 2021/12/16
- Product number
- orb611746
- Product name
- LY450108
- Packaging
- 10mg
- Price
- $588.2
- Updated
- 2021/12/16
- Product number
- CS-1090
- Product name
- LY450108
- Purity
- 99.51%
- Packaging
- 50mg
- Price
- $1267
- Updated
- 2021/12/16
LY 450108 Chemical Properties,Usage,Production
Uses
LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4].
References
[1] Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190. DOI:10.1111/j.1476-5381.2010.00726.x
[2] O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. DOI:10.2174/138945007780618517
[3] Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32. DOI:10.1177/0091270006286899
[4] Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142. DOI:10.1074/jbc.M110.212522
LY 450108 Preparation Products And Raw materials
Raw materials
Preparation Products
LY 450108 Suppliers
- Tel
- 0510-83588313-811 18800520310
- sales@chemshuttle.com
- Country
- China
- ProdList
- 2999
- Advantage
- 62
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 18068075658
- Fax
- -
- sales@chempioneer.com
- Country
- China
- ProdList
- 1811
- Advantage
- 58
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55