ChemicalBook > CAS DataBase List > Skepinone-L

Skepinone-L

Product Name
Skepinone-L
CAS No.
1221485-83-1
Chemical Name
Skepinone-L
Synonyms
CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
CBNumber
CB52628399
Molecular Formula
C24H21F2NO4
Formula Weight
425.42
MOL File
1221485-83-1.mol
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Skepinone-L Property

Melting point:
130-134°C
Boiling point:
629.0±55.0 °C(Predicted)
Density 
1.384±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
13.49±0.20(Predicted)
form 
Solid
color 
Light Yellow to Yellow
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Safety

HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16974
Product name
Skepinone-L
Purity
≥98%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
16974
Product name
Skepinone-L
Purity
≥98%
Packaging
1mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
16974
Product name
Skepinone-L
Purity
≥98%
Packaging
5mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
16974
Product name
Skepinone-L
Purity
≥98%
Packaging
10mg
Price
$665
Updated
2024/03/01
TRC
Product number
S499000
Product name
Skepinone-L
Packaging
25mg
Price
$945
Updated
2021/12/16
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Skepinone-L Chemical Properties,Usage,Production

Description

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.

Uses

Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.

target

p38-MAPK

References

[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.

Skepinone-L Preparation Products And Raw materials

Raw materials

Preparation Products

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Skepinone-L Suppliers

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1221485-83-1, Skepinone-LRelated Search:

Sivelestat sodium Sitaxentan sodium Sitravatinib MK-2206 2HCl 1,9-Pyrazoloanthrone Saracatinib TAK-632 PP2 Fedratinib

  • 5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-
  • Skepinone-L, >=98%
  • 3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
  • (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann
  • Skepinone-L
  • 2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
  • CS-1010
  • SKEPINONE
  • CBS3830
  • Skepinone-L USP/EP/BP
  • Skepinone-L (CBS3830)
  • (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one
  • inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor
  • 1221485-83-1
  • C24H21F2NO4
  • MAPK
  • Inhibitors