ChemicalBook > CAS DataBase List > SSR 240612

SSR 240612

Product Name
SSR 240612
CAS No.
464930-42-5
Chemical Name
SSR 240612
Synonyms
CS-2687;SSR 240612;SSR-240612 HCl;SSR 240612; SSR-240612;SSR 240612 hydrochloride;SSR-240612; SSR240612; SSR 240612;SSR 240612,SSR240612,SSR-240612,Inhibitor,inhibit,Bradykinin Receptor;(R)-2-((R)-3-(Benzo[d][1,3]dioxol-5-yl)-3-(6-methoxynaphthalene-2-sulfonamido)propanamido)-3-(4-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)phenyl)-N-isopropyl-N-methylpropanamide hydrochloride;(2R)-2-[[(3R)-3-(1,3-benzodioxol-5-yl)-3-[(6-methoxynaphthalen-2-yl)sulfonylamino]propanoyl]amino]-3-[4-[[(2S,6R)-2,6-dimethylpiperidin-1-yl]methyl]phenyl]-N-methyl-N-propan-2-ylpropanamide:hydrochloride
CBNumber
CB52628430
Molecular Formula
C42H53ClN4O7S
Formula Weight
793.42
MOL File
464930-42-5.mol
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SSR 240612 Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
form 
A crystalline solid
color 
White to off-white
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Safety

HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25544
Product name
SSR 240612
Purity
≥95%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
25544
Product name
SSR 240612
Purity
≥95%
Packaging
5mg
Price
$422
Updated
2024/03/01
Cayman Chemical
Product number
25544
Product name
SSR 240612
Purity
≥95%
Packaging
10mg
Price
$631
Updated
2024/03/01
Cayman Chemical
Product number
25544
Product name
SSR 240612
Purity
≥95%
Packaging
25mg
Price
$1314
Updated
2024/03/01
TRC
Product number
S684420
Product name
SSR240612
Packaging
2.5mg
Price
$235
Updated
2021/12/16
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SSR 240612 Chemical Properties,Usage,Production

Uses

SSR 240612, is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist.

in vivo

SSR240612 (10 mg/kg p.o. or 0.3, 1 mg/kg i.p.) obviously blocks the des-Arg9-BK-induced paw edema in the mice. SSR240612 (10 and 30 mg/kg) reduces the duration of the late phase of paw licking in a dose dependent manner in the formalin model of inflammation in mice. SSR240612 (0.3, 3, and 30 mg/kg, p.o.) treatment before capsaicin potently and non-concentration-dependently reduces the ear edema. SSR240612 (0.3 mg/kg, i.v.) also suppresses the tissue destruction and neutrophil accumulation in the rat intestine, after splanchnic artery occlusion/reperfusion. Moreover, SSR240612 (1 and 3 mg/kg p.o.) dramacally increases the withdrawal latencies in the thermal hyperalgesia induced by UV irradiation in rats[1]. SSR240612 inhibits tactile and cold allodynia at 3?h in glucose-fed rats but had no effect in control rats with ID50s of 5.5 and 7.1?mg/kg, respectively. SSR240612 shows no effect on plasma glucose and insulin, insulin resistance (HOMA index) and aortic superoxide anion production in glucose-fed rats at 10?mg/kg[2].

IC 50

Bradykinin B1 Receptor (B1R)

SSR 240612 Preparation Products And Raw materials

Raw materials

Preparation Products

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SSR 240612 Suppliers

China 43 India 1 United States 5 Global 49
AdooQ Bioscience CHINA
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464930-42-5, SSR 240612Related Search:

FGFR inhibitor

  • SSR 240612
  • (2R)-2-[[(3R)-3-(1,3-benzodioxol-5-yl)-3-[(6-methoxynaphthalen-2-yl)sulfonylamino]propanoyl]amino]-3-[4-[[(2S,6R)-2,6-dimethylpiperidin-1-yl]methyl]phenyl]-N-methyl-N-propan-2-ylpropanamide:hydrochloride
  • SSR-240612 HCl
  • SSR 240612; SSR-240612
  • SSR-240612; SSR240612; SSR 240612
  • CS-2687
  • SSR 240612 hydrochloride
  • (R)-2-((R)-3-(Benzo[d][1,3]dioxol-5-yl)-3-(6-methoxynaphthalene-2-sulfonamido)propanamido)-3-(4-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)phenyl)-N-isopropyl-N-methylpropanamide hydrochloride
  • SSR 240612,SSR240612,SSR-240612,Inhibitor,inhibit,Bradykinin Receptor
  • 464930-42-5