SSR 240612
- Product Name
- SSR 240612
- CAS No.
- 464930-42-5
- Chemical Name
- SSR 240612
- Synonyms
- CS-2687;SSR 240612;SSR-240612 HCl;SSR 240612; SSR-240612;SSR 240612 hydrochloride;SSR-240612; SSR240612; SSR 240612;SSR 240612,SSR240612,SSR-240612,Inhibitor,inhibit,Bradykinin Receptor;(R)-2-((R)-3-(Benzo[d][1,3]dioxol-5-yl)-3-(6-methoxynaphthalene-2-sulfonamido)propanamido)-3-(4-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)phenyl)-N-isopropyl-N-methylpropanamide hydrochloride;(2R)-2-[[(3R)-3-(1,3-benzodioxol-5-yl)-3-[(6-methoxynaphthalen-2-yl)sulfonylamino]propanoyl]amino]-3-[4-[[(2S,6R)-2,6-dimethylpiperidin-1-yl]methyl]phenyl]-N-methyl-N-propan-2-ylpropanamide:hydrochloride
- CBNumber
- CB52628430
- Molecular Formula
- C42H53ClN4O7S
- Formula Weight
- 793.42
- MOL File
- 464930-42-5.mol
SSR 240612 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
- form
- A crystalline solid
- color
- White to off-white
Safety
- HS Code
- 2935909099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 25544
- Product name
- SSR 240612
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 25544
- Product name
- SSR 240612
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $422
- Updated
- 2024/03/01
- Product number
- 25544
- Product name
- SSR 240612
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $631
- Updated
- 2024/03/01
- Product number
- 25544
- Product name
- SSR 240612
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $1314
- Updated
- 2024/03/01
- Product number
- S684420
- Product name
- SSR240612
- Packaging
- 2.5mg
- Price
- $235
- Updated
- 2021/12/16
SSR 240612 Chemical Properties,Usage,Production
Uses
SSR 240612, is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist.
in vivo
SSR240612 (10 mg/kg p.o. or 0.3, 1 mg/kg i.p.) obviously blocks the des-Arg9-BK-induced paw edema in the mice. SSR240612 (10 and 30 mg/kg) reduces the duration of the late phase of paw licking in a dose dependent manner in the formalin model of inflammation in mice. SSR240612 (0.3, 3, and 30 mg/kg, p.o.) treatment before capsaicin potently and non-concentration-dependently reduces the ear edema. SSR240612 (0.3 mg/kg, i.v.) also suppresses the tissue destruction and neutrophil accumulation in the rat intestine, after splanchnic artery occlusion/reperfusion. Moreover, SSR240612 (1 and 3 mg/kg p.o.) dramacally increases the withdrawal latencies in the thermal hyperalgesia induced by UV irradiation in rats[1]. SSR240612 inhibits tactile and cold allodynia at 3?h in glucose-fed rats but had no effect in control rats with ID50s of 5.5 and 7.1?mg/kg, respectively. SSR240612 shows no effect on plasma glucose and insulin, insulin resistance (HOMA index) and aortic superoxide anion production in glucose-fed rats at 10?mg/kg[2].
IC 50
Bradykinin B1 Receptor (B1R)
SSR 240612 Preparation Products And Raw materials
Raw materials
Preparation Products
SSR 240612 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58