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TBPB

Product Name
TBPB
CAS No.
634616-95-8
Chemical Name
TBPB
Synonyms
TBPB(1%EA);TBPB, 10 mM in DMSO;1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one;2H-BenziMidazol-2-one, 1,3-dihydro-1-[1'-[(2-Methylphenyl)Methyl][1,4'-bipiperidin]-4-yl]-;1-{1'-[(2-methylphenyl)methyl]-[1,4'-bipiperidin]-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
CBNumber
CB52628445
Molecular Formula
C25H32N4O
Formula Weight
404.55
MOL File
634616-95-8.mol
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TBPB Property

Density 
1.193±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution; warmed)
pka
12.04±0.30(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0453
Product name
TBPB
Purity
≥98% (HPLC)
Packaging
5mg
Price
$89.1
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0453
Product name
TBPB
Purity
≥98% (HPLC)
Packaging
25mg
Price
$436
Updated
2022/05/15
Cayman Chemical
Product number
22943
Product name
TBPB
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22943
Product name
TBPB
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
22943
Product name
TBPB
Packaging
10mg
Price
$163
Updated
2024/03/01
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TBPB Chemical Properties,Usage,Production

Uses

TBPB is an allosteric M1 muscarinic acetylcholine receptor activator that regulates amyloid processing and produces antipsychotic-like activity in rats.

Biological Activity

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimerμs. M1 agonists are being studied as potential therapeutic agents to tre at Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

in vivo

TBPB (60 mg/kg; subcutaneous injection; single dose; 2 h before sepsis induction) significantly reduces mortality in E. coli-induced murine sepsis model, with 20% and 23.2% decreases in 4- and 24-hour mortality, while inhibiting TNF-α, IL-1β, and IL-6 levels[3].

Animal Model:Random-bred albino mice (male/female, 18-22 g) with E. coli-induced sepsis[3]
Dosage:60 mg/kg
Administration:Subcutaneous injection, single dose, 2 hours prior to sepsis induction
Result:Reduced 4-hour mortality by 20% and 24-hour mortality by 23.2% compared to vehicle control.
Significantly decreased blood concentrations of TNF-α, IL-1β, and IL-6 by 2.8-, 2.2-, and 7.3-fold respectively at 4 hours post-sepsis induction.

IC 50

mAChR1: 289 nM (EC50)

TBPB Preparation Products And Raw materials

Raw materials

Preparation Products

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TBPB Suppliers

Canada 1 China 55 India 1 The Netherlands 1 United States 10 Global 68
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58
Riedel-de Haen AG
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Fax
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Country
United States
ProdList
6773
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87
Matrix Scientific
Tel
--
Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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80
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View Lastest Price from TBPB manufacturers

Career Henan Chemica Co
Product
TBPB 634616-95-8
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29

634616-95-8, TBPBRelated Search:


  • 2H-BenziMidazol-2-one, 1,3-dihydro-1-[1'-[(2-Methylphenyl)Methyl][1,4'-bipiperidin]-4-yl]-
  • 1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
  • 1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one
  • TBPB(1%EA)
  • 1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one
  • 1-{1'-[(2-methylphenyl)methyl]-[1,4'-bipiperidin]-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • TBPB, 10 mM in DMSO
  • 634616-95-8
  • Inhibitors