Di-tert-butyl Maleate
- Product Name
- Di-tert-butyl Maleate
- CAS No.
- 18305-60-7
- Chemical Name
- Di-tert-butyl Maleate
- Synonyms
- 3-Oxetanol,8-ethynyl-;Bis(2-methyl-2-propanyl)(2Z)-2-butenedioate;2-Butenedioic acid (2Z)-, bis(1,1-dimethylethyl) ester
- CBNumber
- CB52629866
- Molecular Formula
- C12H20O4
- Formula Weight
- 228.28
- MOL File
- 18305-60-7.mol
Di-tert-butyl Maleate Property
- Melting point:
- 64-65 °C
- Boiling point:
- 273.2±13.0 °C(Predicted)
- Density
- 1.004±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Solid
- color
- Off-White
- InChI
- InChI=1S/C12H20O4/c1-11(2,3)15-9(13)7-8-10(14)16-12(4,5)6/h7-8H,1-6H3/b8-7-
- InChIKey
- MSVGHYYKWDQHFV-FPLPWBNLSA-N
- SMILES
- C(OC(C)(C)C)(=O)/C=C\C(OC(C)(C)C)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D493740
- Product name
- Di-tert-butylMaleate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD141231
- Product name
- Di-tert-butyl maleate
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- Z4321
- Product name
- Di-tert-butylmaleate
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FD141231
- Product name
- Di-tert-butyl maleate
- Packaging
- 500mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FD141231
- Product name
- Di-tert-butyl maleate
- Packaging
- 1g
- Price
- $331.25
- Updated
- 2021/12/16
Di-tert-butyl Maleate Chemical Properties,Usage,Production
Uses
Di-tert-butyl Maleate is used as a reactant in the synthesis of J-104,118, a novel, potent inhibitor of squalene synthase.
Synthesis
108-31-6
115-11-7
18305-60-7
Maleic anhydride (13.7 g, 140 mmol), toluene (10 mL), diisopropyl ether (30 mL), water (2.78 mL) and p-toluenesulfonic acid monohydrate were added to a 200 mL four-necked flask and stirred at 30 °C. While maintaining the temperature of the reaction suspension at 30°C, isobutylene gas was passed into the reaction system for 4 hours. Upon completion of the reaction, the unreacted isobutene was expelled through a paraffin bubbler. The reaction mixture was washed sequentially with saturated aqueous sodium bicarbonate (3 x 50 mL) and saturated brine (50 mL), and the organic phase was dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give di-tert-butyl maleate (23.4 g, 102.5 mmol, 73% yield).
References
[1] Patent: JP5754133, 2015, B2. Location in patent: Paragraph 0075
Di-tert-butyl Maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Di-tert-butyl Maleate manufacturers
- Product
- Di-tert-butyl Maleate 18305-60-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19